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Literature summary for 1.1.1.149 extracted from

  • Piekorz, R.P.; Gingras, S.; Hoffmeyer, A.; Ihle, J.N.; Weinstein, Y.
    Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase (2005), Mol. Endocrinol., 19, 431-440.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme expression is induced by interleukin-2 and interleukin-3 in thymocytes and bone marrow cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of gene disruption mutants by homologous recombination lacking enzyme expression and activity, the mutant female mice lack parturition on day 20 of pregnancy, overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17alpha-hydroxyprogesterone + NAD(P)H Mus musculus regulation of enzyme expression during pregnancy, the enzyme is required for prostaglandin F2alpha-dependent progesterone down-regulation before parturition, overview 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland high expression level Mus musculus
-
bone marrow high expression level Mus musculus
-
kidney high expression level Mus musculus
-
ovary high expression level Mus musculus
-
thymus high expression level Mus musculus
-
uterus regulation of enzyme expression during pregnancy Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
quantification of serum progesterone levels Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxyprogesterone + NAD(P)H
-
Mus musculus 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
r
17alpha-hydroxyprogesterone + NAD(P)H regulation of enzyme expression during pregnancy, the enzyme is required for prostaglandin F2alpha-dependent progesterone down-regulation before parturition, overview Mus musculus 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
r

Synonyms

Synonyms Comment Organism
20alpha-HSD
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
Mus musculus
NAD(P)H
-
Mus musculus