Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.149 extracted from

  • Papp, E.; Balogun, K.; Banko, N.; Mohammadi, H.; Loutfy, M.; Yudin, M.; Shah, R.; Macgillivray, J.; Murphy, K.; Walmsley, S.; Silverman, M.; Serghides, L.
    Low prolactin and high 20-alpha-hydroxysteroid dehydrogenase levels contribute to lower progesterone levels in hiv-infected pregnant women exposed to protease inhibitor-based combination antiretroviral therapy (2016), J. Infect. Dis., 213, 1532-1540.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-
trophoblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
progesterone + NADH + H+
-
Homo sapiens 20alpha-hydroxyprogesterone + NAD+
-
?

Synonyms

Synonyms Comment Organism
20-alpha-hydroxysteroid dehydrogenase
-
Homo sapiens
20alpha-HSD
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens human immunodeficiency virus-infected pregnant women receiving protease inhibitor-based combination antiretroviral therapy show an elevation in placental expression of the 20-alpha-hydroxysteroid dehydrogenase up
Homo sapiens placental enzyme expression is significantly elevated in human immunodeficiency virus-infected pregnant women exposed to protease inhibitor-based combination antiretroviral therapy up