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Literature summary for 1.1.1.153 extracted from

  • Katoh, S.; Sueoka, T.; Yamada, S.
    Direct inhibition of brain sepiapterin reductase by a catecholamine and an indoleamine (1982), Biochem. Biophys. Res. Commun., 105, 75-81.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-norepinephrine 3 mM: 30% inhibition Rattus norvegicus
catecholamine
-
Rattus norvegicus
dopamine slight; slight inhibition Rattus norvegicus
Indoleamine
-
Rattus norvegicus
Melatonin 3 mM, almost complete inhibition; strong inhibition Rattus norvegicus
additional information no inhibition by 1-epinephrine, phenylalanine, tyrosine, L-DOPA, L-tryptophan, L-5-hydroxy-tryptophan Rattus norvegicus
N-acetyl-serotonin complete inhibition Rattus norvegicus
N-acetylserotonin 3 mM, complete inhibition Rattus norvegicus
serotonin
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus terminal step in the biosynthetic pathway for tetrahydrobiopterin 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus Sprague-Dawley terminal step in the biosynthetic pathway for tetrahydrobiopterin 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
additional information Rattus norvegicus the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins ?
-
?
additional information Rattus norvegicus Sprague-Dawley the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins ?
-
?
sepiapterin + NADPH + H+ Rattus norvegicus
-
7,8-dihydrobiopterin + NADP+
-
?
sepiapterin + NADPH + H+ Rattus norvegicus Sprague-Dawley
-
7,8-dihydrobiopterin + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley
-
Rattus norvegicus
-
male sprague-dawley rats
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
brain, partially, from erythrocytes to homogeneity Rattus norvegicus
native enzyme partially from brain by ammonium sulfate fractionation and hydroxylapatite chromatography, and from erythrocytes to homogeneity by affinity chromatography and isoelectric focusing Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
brain in all parts of the brain Rattus norvegicus
-
erythrocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Rattus norvegicus Sprague-Dawley 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Rattus norvegicus Sprague-Dawley 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
additional information the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins Rattus norvegicus ?
-
?
additional information the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins Rattus norvegicus Sprague-Dawley ?
-
?
sepiapterin + NADPH + H+
-
Rattus norvegicus 7,8-dihydrobiopterin + NADP+
-
?
sepiapterin + NADPH + H+
-
Rattus norvegicus Sprague-Dawley 7,8-dihydrobiopterin + NADP+
-
?

Synonyms

Synonyms Comment Organism
SR
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00017
-
N-acetyl-serotonin pH 6.4, 25°C, erythrocyte enzyme Rattus norvegicus
0.0002
-
N-acetyl-serotonin pH 6.4, 25°C, brain enzyme Rattus norvegicus
0.025
-
Melatonin pH 6.4, 25°C, erythrocyte enzyme Rattus norvegicus
0.03
-
Melatonin pH 6.4, 25°C, brain enzyme Rattus norvegicus
2.3
-
serotonin pH 6.4, 25°C, brain enzyme Rattus norvegicus
2.5
-
serotonin pH 6.4, 25°C, erythrocyte enzyme Rattus norvegicus
3.1
-
1-norepinephrine pH 6.4, 25°C, erythrocyte enzyme Rattus norvegicus
3.4
-
1-norepinephrine pH 6.4, 25°C, brain enzyme Rattus norvegicus