Literature summary for 1.1.1.153 extracted from

Auerbach, G.; Herrmann, A.; Gutlich, M.; Fischer, M.; Jacob, U.; Bacher, A.; Huber, R.
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters (1997), EMBO J., 16, 7219-7230.

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Cloned(Commentary)

Cloned (Comment)	Organism
recombinant protein expressed in Escherichia coli	Mus musculus

Crystallization (Commentary)

Crystallization (Comment)	Organism
vapour diffusion technique	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
N-acetylserotonin	-	Mus musculus
N-chloroserotonin	strong inhibitor	Mus musculus
N-methoxyacetylserotonin	strong competitive inhibitor	Mus musculus
oxaloacetate	-	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH	Mus musculus	-	6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q64105	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant protein of Escherichia coli	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH	-	Mus musculus	6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+	-	?

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Release 2023.1 (January 2023)