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Literature summary for 1.1.1.153 extracted from

  • Sawabe, K.; Yamamoto, K.; Harada, Y.; Ohashi, A.; Sugawara, Y.; Matsuoka, H.; Hasegawa, H.
    Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin (2008), Mol. Genet. Metab., 94, 410-416.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-acetylserotonin
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH Homo sapiens
-
tetrahydrobiopterin + NADP+
-
r
additional information Homo sapiens sepiapterin or dihydrobiopterin are the precursors of the tetrahydrobiopterin-salvage pathway, enzyme activity and pathway regulation in vivo, overview ?
-
?
sepiapterin + NADPH + H+ Homo sapiens cellular uptake of sepiapterin across the cell membrane results in an efficient accumulation of tetrahydrobiopterin, sepiapterin relocates across the plasma membrane via two distinct paths, the slower path connects to the cytosolic compartment, overview 7,8-dihydrobiopterin + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
-
Homo sapiens tetrahydrobiopterin + NADP+
-
r
additional information sepiapterin or dihydrobiopterin are the precursors of the tetrahydrobiopterin-salvage pathway, enzyme activity and pathway regulation in vivo, overview Homo sapiens ?
-
?
sepiapterin + NADPH + H+
-
Homo sapiens 7,8-dihydrobiopterin + NADP+
-
r
sepiapterin + NADPH + H+ cellular uptake of sepiapterin across the cell membrane results in an efficient accumulation of tetrahydrobiopterin, sepiapterin relocates across the plasma membrane via two distinct paths, the slower path connects to the cytosolic compartment, overview Homo sapiens 7,8-dihydrobiopterin + NADP+
-
r