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Literature summary for 1.1.1.159 extracted from

  • Tanaka, N.; Nonaka, T.; Tanabe, T.; Yoshimoto, T.; Tsuru, D.; Mitsui, Y.
    Crystal structures of the binary and ternary complexes of 7alpha-hydroxysteroid dehydrogenase from Escherichia coli (1996), Biochemistry, 35, 7715-7730.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
binary complex with NAD+, ternary complex with NADH and 7-oxoglycochenodeoxycholic acid as product, as well as possibly partially glycochenodeoxycholic acid as substrat Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bile acids + NAD(P)+ Escherichia coli dehydrogenation of hydroxyl group at position 7, wide variety of substrate binding specificities in short-chain dehydrogenase enzyme family ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0AET8
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Reaction

Reaction Comment Organism Reaction ID
cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate + NADH + H+ belongs to the short-chain dehydrogenase/reductase 1 familiy (SDR), mechanism Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bile acids + NAD(P)+ dehydrogenation of hydroxyl group at position 7, wide variety of substrate binding specificities in short-chain dehydrogenase enzyme family Escherichia coli ?
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Escherichia coli