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Literature summary for 1.1.1.162 extracted from
- D-erythrulose reductase can also reduce diacetyl: further purification and characterization of D-erythrulose reductase from chicken liver (1998), J. Biochem., 123, 602-606.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
Phenanthrenequinone | - |
Gallus gallus |  |
| 0.11 | - |
D-erythrulose | - |
Gallus gallus | |
| 0.19 | - |
3,4-hexanedione | - |
Gallus gallus | |
| 0.24 | - |
2,3-Pentanedione | - |
Gallus gallus | |
| 0.26 | - |
2,3-heptanedione | - |
Gallus gallus | |
| 0.39 | - |
diacetyl | - |
Gallus gallus | |
| 0.67 | - |
1,2-Cyclohexanedione | - |
Gallus gallus | |
| 0.68 | - |
(1S)-(+)-Camphorquinone | - |
Gallus gallus | |
| 0.72 | - |
isatin | - |
Gallus gallus | |
| 1.1 | - |
ethyl pyruvate | - |
Gallus gallus | |
| 1.1 | - |
Methyl pyruvate | - |
Gallus gallus | |
| 13 | - |
acetoin | - |
Gallus gallus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diacetyl + NAD(P)H | Gallus gallus | reaction is also performed by acetoin:NAD+ oxidoreductase, EC 1.1.1.5 | acetoin + NADP+ | - |
ir | |
| diacetyl + NAD(P)H | Gallus gallus | detoxification of food derived dicarbonyls | acetoin + NADP+ | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Gallus gallus | - |
| brain | - |
Gallus gallus | - |
| heart | - |
Gallus gallus | - |
| intestine | - |
Gallus gallus | - |
| kidney | - |
Gallus gallus | - |
| liver | - |
Gallus gallus | - |
| additional information | minimal activity also in lens, spleen, lung and pancreas | Gallus gallus | - |
| stomach | - |
Gallus gallus | - |
| testis | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.021 | - |
acetoin | Gallus gallus |
| 64 | - |
(1S)-(+)-camphorquinone | Gallus gallus |
| 77 | - |
methyl pyruvate | Gallus gallus |
| 83 | - |
phenanthrenequione | Gallus gallus |
| 120 | - |
2,3-pentanedione | Gallus gallus |
| 120 | - |
ethyl pyruvate | Gallus gallus |
| 120 | - |
1,2-cyclohexanedione | Gallus gallus |
| 130 | - |
diacetyl | Gallus gallus |
| 180 | - |
2,3-heptanedione | Gallus gallus |
| 200 | - |
3,4-hexanedione | Gallus gallus |
| 250 | - |
isatin | Gallus gallus |
| 320 | - |
purified enzyme, D-erythrulose | Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (1S)-(+)-camphorquinone + NADPH | stereospecific | Gallus gallus | ? | - |
? | |
| 1,2-cyclohexanedione + NADPH | - |
Gallus gallus | ? | - |
? | |
| 2,3-heptanedione + NADPH | - |
Gallus gallus | ? | - |
? | |
| 2,3-pentanedione + NADPH | - |
Gallus gallus | ? | - |
? | |
| 3,4-hexanedione + NADPH | - |
Gallus gallus | ? | - |
? | |
| acetoin + NADPH + H+ | only slight reversibility, low activity | Gallus gallus | 2,3-butanediol + NADP+ | - |
r | |
| D-erythrulose + NAD(P)H | - |
Gallus gallus | D-threitol + NAD(P)+ | - |
r | |
| diacetyl + NAD(P)H | utilizes mainly vicinal alpha-dicarbonyls | Gallus gallus | acetoin + NADP+ | - |
? | |
| diacetyl + NAD(P)H | utilizes mainly vicinal alpha-dicarbonyls | Gallus gallus | acetoin + NADP+ | - |
ir | |
| diacetyl + NAD(P)H | reaction is also performed by acetoin:NAD+ oxidoreductase, EC 1.1.1.5 | Gallus gallus | acetoin + NADP+ | - |
? | |
| diacetyl + NAD(P)H | reaction is also performed by acetoin:NAD+ oxidoreductase, EC 1.1.1.5 | Gallus gallus | acetoin + NADP+ | - |
ir | |
| diacetyl + NAD(P)H | specific for alpha-dicarbonyls | Gallus gallus | acetoin + NADP+ | - |
? | |
| diacetyl + NAD(P)H | specific for alpha-dicarbonyls | Gallus gallus | acetoin + NADP+ | - |
ir | |
| diacetyl + NAD(P)H | detoxification of food derived dicarbonyls | Gallus gallus | acetoin + NADP+ | - |
ir | |
| ethyl pyruvate + NADPH | - |
Gallus gallus | ethyllactate + NADP+ | - |
? | |
| isatin + NADPH | s-cis configuration of the neighbouring carbonyls is important for activity | Gallus gallus | ? | - |
? | |
| methyl pyruvate + NADPH | - |
Gallus gallus | methyllactate + NADP+ | - |
? | |
| Phenanthrenequinone + NADPH | s-cis configuration of the neighbouring carbonyls is important for activity | Gallus gallus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.8 | 6 | diacetyl + NADPH | Gallus gallus |
| 6 | 6.8 | diacetyl + NADH | Gallus gallus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 9 | oxidation of acetoin to 2,3-butanediol | Gallus gallus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Gallus gallus | |
| NADP+ | - |
Gallus gallus | |
| NADPH | - |
Gallus gallus | |
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