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Literature summary for 1.1.1.168 extracted from

  • Hata, H.; Shimizu, S.; Hattori, S.; Yamada, H.
    Ketopantoyl-lactone reductase is a conjugated polyketone reductase (1989), FEMS Microbiol. Lett., 58, 87-90.
    View publication on PubMed
Search for more literature for 1.1.1.168

Inhibitors

Inhibitors Comment Organism Structure
ketopantoyl lactone
-
 Saccharomyces cerevisiae
Polyketones cyclohexenediol-1,2,3,4-tetraone; e.g. parabanic acid Saccharomyces cerevisiae
quercetin
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0031
-
 5-bromoisatin
-
 Saccharomyces cerevisiae
0.0057
-
 1-methylisatin
-
 Saccharomyces cerevisiae
0.0066
-
 isatin
-
 Saccharomyces cerevisiae
0.0083
-
 5-methylisatin
-
 Saccharomyces cerevisiae
0.0093
-
 dihydro-5-isopropyl-4,4-dimethyl-2,3-furanedione
-
 Saccharomyces cerevisiae
0.0098
-
 dihydro-5-(3-pentyl)-4,4-dimethyl-2,3-furanedione
-
 Saccharomyces cerevisiae
0.013
-
 dihydro-5-(2-pentyl)-4,4-dimethyl-2,3-furanedione
-
 Saccharomyces cerevisiae
0.043
-
 dihydro-5-(2-butyl)-4-methyl-4-ethyl-2,3-furanedione
-
 Saccharomyces cerevisiae
0.064
-
 dl-camphorquinone
-
 Saccharomyces cerevisiae
0.09
-
 dihydro-5-(2-pentyl)-4-methyl-4-propyl-2,3-furanedione
-
 Saccharomyces cerevisiae
0.093
-
 beta-naphthoquinone
-
 Saccharomyces cerevisiae
0.17
-
 ketopantoyl lactone
-
 Saccharomyces cerevisiae
0.42
-
 dihydro-4,4-diethyl-2,3-furanedione
-
 Saccharomyces cerevisiae
0.52
-
 ninhydrin
-
 Saccharomyces cerevisiae
0.83
-
 alloxan
-
 Saccharomyces cerevisiae
0.983
-
 dihydro-4-methyl-4-propyl-2,3-furanedione
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-dehydropantoyl lactone + NADPH Saccharomyces cerevisiae
-
 (R)-pantoyl lactone + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methylisatin + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
2-dehydropantoyl lactone + NADPH
-
 Saccharomyces cerevisiae (R)-pantoyl lactone + NADP+
-
 ?
5-bromoisatin + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
5-methylisatin + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
alloxan + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
beta-naphthoquinone + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
bornanedione + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
camphorquinone + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
dihydro-4,4-diethyl-2,3-furanedione + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
dihydro-4-methyl-4-propyl-2,3-furanedione + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
dihydro-5-(2-butyl)-4-methyl-4-ethyl-2,3-furanedione + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
dihydro-5-(2-pentyl)-4,4-dimethyl-2,3-furanedione + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
dihydro-5-(2-pentyl)-4-methyl-4-propyl-2,3-furanedione + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
dihydro-5-(3-pentyl)-4,4-dimethyl-2,3-furanedione + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
dihydro-5-isopropyl-4,4-dimethyl-2,3-furanedione + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
isatin + NADPH and its derivatives Saccharomyces cerevisiae ?
-
 ?
ketopantoyl lactone + NADPH and its derivatives Saccharomyces cerevisiae D-(-)-pantoyl lactone
-
 ?
ketopantoyl lactone + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
additional information carbonyl reductase specifically catalyzing the reduction of conjugated polyketones Saccharomyces cerevisiae additional information
-
 ?
naphthoquinone + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?
ninhydrin + NADPH
-
 Saccharomyces cerevisiae ?
-
 ?