Cloned (Comment) | Organism |
---|---|
expression of isozymes CHCR1-3 as His-tagged proteins in Escherichia coli strain BL21(DE3) | Cricetulus griseus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Acetylsalicylate | IC50 for the 3 isozymes CHCR1-3, overview | Cricetulus griseus | |
cibacron | IC50 for the 3 isozymes CHCR1-3, overview | Cricetulus griseus | |
Ethacrynic acid | IC50 for the 3 isozymes CHCR1-3, overview | Cricetulus griseus | |
indomethacin | IC50 for the 3 isozymes CHCR1-3, overview | Cricetulus griseus | |
megestrol acetate | IC50 for the 3 isozymes CHCR1-3, overview | Cricetulus griseus | |
methyltestosterone | IC50 for the 3 isozymes CHCR1-3, overview | Cricetulus griseus | |
Norethindrone | IC50 for the 3 isozymes CHCR1-3, overview | Cricetulus griseus | |
pyrazole | IC50 for the 3 isozymes CHCR1-3, overview | Cricetulus griseus | |
pyruvate | inactivation of isozyme CHCR2, not of isozymes CHCR1 and 3 | Cricetulus griseus | |
quercitrin | IC50 for the 3 isozymes CHCR1-3, overview | Cricetulus griseus | |
warfarin | IC50 for the 3 isozymes CHCR1-3, overview | Cricetulus griseus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
31000 | - |
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE | Cricetulus griseus |
32000 | - |
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE | Cricetulus griseus |
34000 | - |
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE | Cricetulus griseus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
3 isozymes CHCR1-3 | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged isozymes CHCR1-3 from Escherichia coli strain BL21(DE3) | Cricetulus griseus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | strong expression of isozyme CHCR1, weaker expression of isozyme CHCR2, no expression of isozyme CHCR3 | Cricetulus griseus | - |
kidney | strong expression of all 3 isozyme in descending order CHCR1, CHCR2, CHCR3 | Cricetulus griseus | - |
liver | moderate expression of all 3 isozyme in descending order CHCR1, CHCR2, CHCR3 | Cricetulus griseus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-benzoylpyridine + NADPH + H+ | isozymes CHCR1-3 | Cricetulus griseus | (S)-alpha-phenyl-4-pyridylmethanol + NADP+ | - |
ir | |
4-pregnen-3,20-dione + NADPH | isozymes CHCR1-3 | Cricetulus griseus | ? | - |
ir | |
5alpha-androstan-17beta-ol-3-one + NADPH | isozymes CHCR1-3 | Cricetulus griseus | ? | - |
ir | |
5alpha-androstane-3,17-dione + NADPH | isozymes CHCR1-3 | Cricetulus griseus | ? | - |
ir | |
5alpha-androstane-3alpha,17beta-diol + NADPH | isozymes CHCR1-3 | Cricetulus griseus | ? | - |
r | |
5beta-androstane-3,17-dione + NADPH | isozymes CHCR1-3 | Cricetulus griseus | ? | - |
ir | |
5beta-pregnan-3beta-ol-20-one + NADPH | isozymes CHCR1-3 | Cricetulus griseus | ? | - |
r | |
daunorubicin + NADPH | isozymes CHCR1-3 | Cricetulus griseus | ? | - |
ir | |
DELTA4-androstan-17beta-ol-3-one + NADPH | isozymes CHCR1-3 | Cricetulus griseus | ? | - |
r | |
isatin + NADPH | isozymes CHCR1-3 | Cricetulus griseus | ? | - |
ir | |
additional information | substrate specificities of the 3 isozymes, overview, no activity with 5alpha-androstan-3beta-ol-17-one | Cricetulus griseus | ? | - |
? | |
prostaglandin A1 + NADPH | isozymes CHCR1 and 2, no activity with isozyme CHCR3 | Cricetulus griseus | ? | - |
r | |
prostaglandin A2 + NADPH | isozymes CHCR1 and 2, no activity with isozyme CHCR3 | Cricetulus griseus | ? | - |
r | |
prostaglandin B2 + NADPH | isozymes CHCR1 and 2, no activity with isozyme CHCR3 | Cricetulus griseus | ? | - |
r | |
prostaglandin D2 + NADPH | isozymes CHCR1 and 2, no activity with isozyme CHCR3 | Cricetulus griseus | ? | - |
r | |
prostaglandin E2 + NADPH | isozymes CHCR1 and 2, no activity with isozyme CHCR3 | Cricetulus griseus | ? | - |
r | |
prostaglandin F2alpha + NADPH | isozymes CHCR1 and 2, no activity with isozyme CHCR3 | Cricetulus griseus | ? | - |
r |
Subunits | Comment | Organism |
---|---|---|
? | x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE | Cricetulus griseus |
Synonyms | Comment | Organism |
---|---|---|
carbonyl reductase | - |
Cricetulus griseus |
CHCR | - |
Cricetulus griseus |
CR | - |
Cricetulus griseus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Cricetulus griseus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Cricetulus griseus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Cricetulus griseus |