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Literature summary for 1.1.1.184 extracted from

  • Terada, T.; Sugihara, Y.; Nakamura, K.; Mizobuchi, H.; Maeda, M.
    Further characterization of chinese hamster carbonyl reductases (CHCRs) (2003), Chem. Biol. Interact., 143-144, 373-381.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of isozymes CHCR1-3 as His-tagged proteins in Escherichia coli strain BL21(DE3) Cricetulus griseus

Inhibitors

Inhibitors Comment Organism Structure
Acetylsalicylate IC50 for the 3 isozymes CHCR1-3, overview Cricetulus griseus
cibacron IC50 for the 3 isozymes CHCR1-3, overview Cricetulus griseus
Ethacrynic acid IC50 for the 3 isozymes CHCR1-3, overview Cricetulus griseus
indomethacin IC50 for the 3 isozymes CHCR1-3, overview Cricetulus griseus
megestrol acetate IC50 for the 3 isozymes CHCR1-3, overview Cricetulus griseus
methyltestosterone IC50 for the 3 isozymes CHCR1-3, overview Cricetulus griseus
Norethindrone IC50 for the 3 isozymes CHCR1-3, overview Cricetulus griseus
pyrazole IC50 for the 3 isozymes CHCR1-3, overview Cricetulus griseus
pyruvate inactivation of isozyme CHCR2, not of isozymes CHCR1 and 3 Cricetulus griseus
quercitrin IC50 for the 3 isozymes CHCR1-3, overview Cricetulus griseus
warfarin IC50 for the 3 isozymes CHCR1-3, overview Cricetulus griseus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE Cricetulus griseus
32000
-
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE Cricetulus griseus
34000
-
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
3 isozymes CHCR1-3
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged isozymes CHCR1-3 from Escherichia coli strain BL21(DE3) Cricetulus griseus

Source Tissue

Source Tissue Comment Organism Textmining
brain strong expression of isozyme CHCR1, weaker expression of isozyme CHCR2, no expression of isozyme CHCR3 Cricetulus griseus
-
kidney strong expression of all 3 isozyme in descending order CHCR1, CHCR2, CHCR3 Cricetulus griseus
-
liver moderate expression of all 3 isozyme in descending order CHCR1, CHCR2, CHCR3 Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-benzoylpyridine + NADPH + H+ isozymes CHCR1-3 Cricetulus griseus (S)-alpha-phenyl-4-pyridylmethanol + NADP+
-
ir
4-pregnen-3,20-dione + NADPH isozymes CHCR1-3 Cricetulus griseus ?
-
ir
5alpha-androstan-17beta-ol-3-one + NADPH isozymes CHCR1-3 Cricetulus griseus ?
-
ir
5alpha-androstane-3,17-dione + NADPH isozymes CHCR1-3 Cricetulus griseus ?
-
ir
5alpha-androstane-3alpha,17beta-diol + NADPH isozymes CHCR1-3 Cricetulus griseus ?
-
r
5beta-androstane-3,17-dione + NADPH isozymes CHCR1-3 Cricetulus griseus ?
-
ir
5beta-pregnan-3beta-ol-20-one + NADPH isozymes CHCR1-3 Cricetulus griseus ?
-
r
daunorubicin + NADPH isozymes CHCR1-3 Cricetulus griseus ?
-
ir
DELTA4-androstan-17beta-ol-3-one + NADPH isozymes CHCR1-3 Cricetulus griseus ?
-
r
isatin + NADPH isozymes CHCR1-3 Cricetulus griseus ?
-
ir
additional information substrate specificities of the 3 isozymes, overview, no activity with 5alpha-androstan-3beta-ol-17-one Cricetulus griseus ?
-
?
prostaglandin A1 + NADPH isozymes CHCR1 and 2, no activity with isozyme CHCR3 Cricetulus griseus ?
-
r
prostaglandin A2 + NADPH isozymes CHCR1 and 2, no activity with isozyme CHCR3 Cricetulus griseus ?
-
r
prostaglandin B2 + NADPH isozymes CHCR1 and 2, no activity with isozyme CHCR3 Cricetulus griseus ?
-
r
prostaglandin D2 + NADPH isozymes CHCR1 and 2, no activity with isozyme CHCR3 Cricetulus griseus ?
-
r
prostaglandin E2 + NADPH isozymes CHCR1 and 2, no activity with isozyme CHCR3 Cricetulus griseus ?
-
r
prostaglandin F2alpha + NADPH isozymes CHCR1 and 2, no activity with isozyme CHCR3 Cricetulus griseus ?
-
r

Subunits

Subunits Comment Organism
? x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE Cricetulus griseus

Synonyms

Synonyms Comment Organism
carbonyl reductase
-
Cricetulus griseus
CHCR
-
Cricetulus griseus
CR
-
Cricetulus griseus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Cricetulus griseus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Cricetulus griseus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Cricetulus griseus