Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.188 extracted from

  • Watanabe, K.; Fujii, Y.; Nakayama, K.; Ohkubo, H.; Kuramitsu, S.; Hayashi, H.; Kagamiyama, H.; Nakanishi, S.; Hayaishi, O.
    Cloning, nucleotide sequence and gene expression of bovine lung prostaglandin F synthetase (1988), Adv. Prostaglandin Thromboxane Leukot. Res., 19, 462-465.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung two different active sites Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
-
Bos taurus (5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+
-
?
additional information two different active sites, one for the endoperoxide group of prostaglandin H2 and the other one for the keto group of prostaglandin D2 and other carbonyl compounds Bos taurus ?
-
?
prostaglandin H2 + NADPH + H+
-
Bos taurus (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Bos taurus