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Literature summary for 1.1.1.19 extracted from

  • Bhatnagar, A.; Das, B.; Liu, S.Q.; Srivastava, S.K.
    Human liver aldehyde reductase: pH dependence of steady-state kinetic parameters (1991), Arch. Biochem. Biophys., 287, 329-336.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ATP-ribose competitive versus NADPH Homo sapiens
menadione competitive versus D-glucuronate Homo sapiens
pyridoxal 5'-phosphate
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Homo sapiens
-
L-gulonate + NADP+
-
r
L-gulonate + NADP+ Homo sapiens
-
D-glucuronate + NADPH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
r
L-gulonate + NADP+
-
Homo sapiens D-glucuronate + NADPH
-
r

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information 0.119 per mM * s, L-gulonate, steady state kinetic Homo sapiens
additional information
-
additional information 10.82 per mM * s, D-glucuronate, steady state kinetic Homo sapiens
additional information
-
additional information 1124 per mM * s, NADPH, steady state kinetic Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
substrate L-gulonate or D-glucuronate Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7 10
-
Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
5 10.5 irreversible loss of activity below pH 5.0 and above pH 11 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens