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Literature summary for 1.1.1.2 extracted from

  • Flynn, T.G.; Shires, J.; Walton, D.J.
    Properties of the nicotinamide adenine dinucleotide phosphate-dependent aldehyde reductase from pig kidney. Amino acid composition, reactivity of cysteinyl residues, and stereochemistry of D-glyceraldehyde reduction (1975), J. Biol. Chem., 250, 2933-2940.
    View publication on PubMed
Search for more literature for 1.1.1.2

General Stability

General Stability Organism
presence of p-mercuribenzoate at pH 7, no loss of activity Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
p-mercuribenzoate above 1 mM Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
 gel filtration, ultracentrifugation, specific activity corresponding to molecular weight Sus scrofa
30200
-
-
 Sus scrofa
33000
-
 gel filtration Sus scrofa
36900
-
 1 * 36900, SDS-PAGE Sus scrofa
38000
-
 1 * 38000, SDS-PAGE Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Sus scrofa
-
 L-gulonate + NADP+
-
 r
D-glucuronate + NADPH Oryctolagus cuniculus
-
 L-gulonate + NADP+
-
 r
D-glyceraldehyde + NADPH + H+ Sus scrofa
-
 glycerol + NADP+
-
 r
D-glyceraldehyde + NADPH + H+ Oryctolagus cuniculus
-
 glycerol + NADP+
-
 r
L-gulonic acid + NADP+ Sus scrofa
-
 D-glucuronic acid + NADPH
-
 r
L-gulonic acid + NADP+ Oryctolagus cuniculus
-
 D-glucuronic acid + NADPH
-
 r

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
 rabbit
-
Sus scrofa
-
 pig
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-
kidney
-
 Oryctolagus cuniculus
-
liver
-
 Sus scrofa
-
liver
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.7
-
-
 Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-pyridinecarboxaldehyde + NADPH
-
 Sus scrofa 3-pyridinemethanol + NADP+
-
 r
3-pyridinecarboxaldehyde + NADPH
-
 Oryctolagus cuniculus 3-pyridinemethanol + NADP+
-
 r
D-arabinose + NADPH
-
 Sus scrofa ? + NADP+
-
 ?
D-erythrose + NADPH
-
 Sus scrofa ? + NADP+
-
 ?
D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 ?
D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 r
D-glucuronate + NADPH
-
 Oryctolagus cuniculus L-gulonate + NADP+
-
 ?
D-glucuronate + NADPH
-
 Oryctolagus cuniculus L-gulonate + NADP+
-
 r
D-glyceraldehyde + NADPH + H+
-
 Sus scrofa glycerol + NADP+
-
 r
D-glyceraldehyde + NADPH + H+
-
 Oryctolagus cuniculus glycerol + NADP+
-
 r
L-gulonic acid + NADP+
-
 Sus scrofa D-glucuronic acid + NADPH
-
 r
L-gulonic acid + NADP+
-
 Oryctolagus cuniculus D-glucuronic acid + NADPH
-
 r
L-gulonic acid + NADPH
-
 Sus scrofa D-glucuronic acid + NADP+
-
 r
L-gulonic acid + NADPH
-
 Oryctolagus cuniculus D-glucuronic acid + NADP+
-
 r
p-nitrobenzaldehyde + NADPH
-
 Sus scrofa p-nitrobenzylalcohol + NADP+
-
 r
p-nitrobenzaldehyde + NADPH
-
 Oryctolagus cuniculus p-nitrobenzylalcohol + NADP+
-
 r

Subunits

Subunits Comment Organism
monomer 1 * 38000, SDS-PAGE Sus scrofa
monomer 1 * 36900, SDS-PAGE Sus scrofa

Synonyms

Synonyms Comment Organism
D-glucuronate reductase
-
 Sus scrofa
TPN-L-hexonate dehydrogenase
-
 Sus scrofa