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Literature summary for 1.1.1.2 extracted from
- Kinetic mechanism of sheep liver NADPH-dependent aldehyde reductase (1987), Biochem. J., 242, 143-150.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-ethylhexanoate | - |
Ovis aries |  |
| Alrestatin | liver ALR1 | Ovis aries | |
| D-glucuronate | high concentrations, inhibition in a non-competitive manner | Ovis aries | |
| Phenobarbitone | - |
Ovis aries | |
| pyridine 3-aldehyde | - |
Ovis aries | |
| sodium valproate | - |
Bos taurus | |
| sodium valproate | liver ALR1 | Ovis aries | |
| sorbinil | liver ALR1 | Ovis aries | |
| sorbinil | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
NADPH | p-nitrobenzaldehyde as substrate | Ovis aries | |
| 0.0016 | - |
NADPH | pyridine 3-aldehyde as substrate | Ovis aries | |
| 0.0019 | - |
NADPH | D-glucuronate as substrate | Ovis aries | |
| 0.044 | - |
p-nitrobenzaldehyde | - |
Ovis aries | |
| 1.2 | - |
p-nitrobenzaldehyde | - |
Ovis aries | |
| 1.5 | - |
D-glucuronate | - |
Ovis aries | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | Rattus norvegicus | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Bos taurus | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Ovis aries | - |
L-gulonate + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
ox | - |
| Ovis aries | - |
sheep | - |
| Ovis aries | - |
Suffolk-Hampshire | - |
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ALR1 | Ovis aries |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| brain | - |
Ovis aries | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Bos taurus | - |
| kidney | - |
Ovis aries | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | - |
Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 3-pyridinemethanol + NADP+ | - |
r | |
| 3-pyridinecarboxaldehyde + NADPH | - |
Bos taurus | 3-pyridinemethanol + NADP+ | - |
? | |
| 3-pyridinecarboxaldehyde + NADPH | - |
Ovis aries | 3-pyridinemethanol + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Ovis aries | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Ovis aries | L-gulonate + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Rattus norvegicus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Bos taurus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Ovis aries | p-nitrobenzylalcohol + NADP+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| daunorubicin reductase | - |
Rattus norvegicus |
| daunorubicin reductase | - |
Ovis aries |
| L-hexonate dehydrogenase | - |
Bos taurus |
| L-hexonate dehydrogenase | - |
Ovis aries |
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Release 2023.1 (January 2023)
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