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Literature summary for 1.1.1.2 extracted from

  • Barski, O.A.; Gabbay, K.H.; Grimshaw, C.E.; Bohren, K.M.
    Mechanism of human aldehyde reductase: characterization of the active site pocket (1995), Biochemistry, 34, 11264-11275.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
AL1576
-
Homo sapiens
Alrestatin
-
Homo sapiens
FK366
-
Homo sapiens
ponalrestat
-
Homo sapiens
Tolrestat
-
Homo sapiens
zopolrestat
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.038
-
p-Carboxybenzaldehyde wild-type aldehyde reductase Homo sapiens
0.1
-
p-Carboxybenzaldehyde aldehyde reductase, mutant V299C Homo sapiens
0.16
-
p-nitrobenzaldehyde wild-type aldehyde reductase Homo sapiens
0.17
-
Succinic semialdehyde wild-type aldehyde reductase Homo sapiens
0.38
-
p-nitrobenzaldehyde aldehyde reductase, mutant V299C Homo sapiens
0.38
-
p-Carboxybenzaldehyde aldehyde reductase, mutant I298A Homo sapiens
0.41
-
Succinic semialdehyde aldehyde reductase, mutant V299C Homo sapiens
0.43
-
p-Carboxybenzaldehyde aldehyde reductase, mutant I298C Homo sapiens
1.2
-
p-nitrobenzaldehyde aldehyde reductase, mutant I298C Homo sapiens
1.5
-
Succinic semialdehyde aldehyde reductase, mutant I298C Homo sapiens
1.7
-
DL-glyceraldehyde wild-type aldehyde reductase Homo sapiens
1.7
-
DL-glyceraldehyde wild type enzyme, at pH 7.0 and 25°C Homo sapiens
1.8
-
DL-glyceraldehyde aldehyde reductase, mutant V299C Homo sapiens
1.8
-
DL-glyceraldehyde mutant enzyme V299C, at pH 7.0 and 25°C Homo sapiens
2.8
-
Succinic semialdehyde aldehyde reductase, mutant I298A Homo sapiens
2.8
-
p-nitrobenzaldehyde aldehyde reductase, mutant I298A Homo sapiens
2.8
-
p-Carboxybenzaldehyde aldehyde reductase, mutant H112Q Homo sapiens
4.2
-
D-glucuronate wild-type aldehyde reductase Homo sapiens
4.2
-
D-glucuronate aldehyde reductase, mutant V299C Homo sapiens
5.9
-
p-nitrobenzaldehyde aldehyde reductase, mutant H112Q Homo sapiens
11.5
-
DL-glyceraldehyde aldehyde reductase, mutant I298C Homo sapiens
11.5
-
DL-glyceraldehyde mutant enzyme I298C, at pH 7.0 and 25°C Homo sapiens
18
-
Succinic semialdehyde aldehyde reductase, mutant H112Q Homo sapiens
19.5
-
D-glucuronate aldehyde reductase, mutant I298C Homo sapiens
26.3
-
D-glucuronate aldehyde reductase, mutant I298A Homo sapiens
33
-
DL-glyceraldehyde aldehyde reductase, mutant I298A Homo sapiens
33
-
DL-glyceraldehyde mutant enzyme I298A, at pH 7.0 and 25°C Homo sapiens
48
-
D-glucuronate aldehyde reductase, mutant H112Q Homo sapiens
76
-
DL-glyceraldehyde aldehyde reductase, mutant H112Q Homo sapiens
76
-
DL-glyceraldehyde mutant enzyme H112Q, at pH 7.0 and 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Homo sapiens
-
L-gulonate + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Homo sapiens
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Homo sapiens
-
glycerol + NADP+
-
r
succinic semialdehyde + NADPH + H+ Homo sapiens
-
4-hydroxybutyrate + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Purification (Commentary)

Purification (Comment) Organism
wild-type aldehyde reductase and mutant A H112Q Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
DL-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Homo sapiens glycerol + NADP+
-
r
p-carboxybenzaldehyde + NADPH
-
Homo sapiens p-carboxybenzyl alcohol + NADP+
-
r
p-nitrobenzaldehyde + NADPH
-
Homo sapiens p-nitrobenzylalcohol + NADP+
-
r
succinic semialdehyde + NADPH + H+
-
Homo sapiens 4-hydroxybutyrate + NADP+
-
r

pH Range

pH Minimum pH Maximum Comment Organism
5.5 10
-
Homo sapiens