Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AL1576 | - |
Homo sapiens | |
Alrestatin | - |
Homo sapiens | |
FK366 | - |
Homo sapiens | |
ponalrestat | - |
Homo sapiens | |
Tolrestat | - |
Homo sapiens | |
zopolrestat | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.038 | - |
p-Carboxybenzaldehyde | wild-type aldehyde reductase | Homo sapiens | |
0.1 | - |
p-Carboxybenzaldehyde | aldehyde reductase, mutant V299C | Homo sapiens | |
0.16 | - |
p-nitrobenzaldehyde | wild-type aldehyde reductase | Homo sapiens | |
0.17 | - |
Succinic semialdehyde | wild-type aldehyde reductase | Homo sapiens | |
0.38 | - |
p-nitrobenzaldehyde | aldehyde reductase, mutant V299C | Homo sapiens | |
0.38 | - |
p-Carboxybenzaldehyde | aldehyde reductase, mutant I298A | Homo sapiens | |
0.41 | - |
Succinic semialdehyde | aldehyde reductase, mutant V299C | Homo sapiens | |
0.43 | - |
p-Carboxybenzaldehyde | aldehyde reductase, mutant I298C | Homo sapiens | |
1.2 | - |
p-nitrobenzaldehyde | aldehyde reductase, mutant I298C | Homo sapiens | |
1.5 | - |
Succinic semialdehyde | aldehyde reductase, mutant I298C | Homo sapiens | |
1.7 | - |
DL-glyceraldehyde | wild-type aldehyde reductase | Homo sapiens | |
1.7 | - |
DL-glyceraldehyde | wild type enzyme, at pH 7.0 and 25°C | Homo sapiens | |
1.8 | - |
DL-glyceraldehyde | aldehyde reductase, mutant V299C | Homo sapiens | |
1.8 | - |
DL-glyceraldehyde | mutant enzyme V299C, at pH 7.0 and 25°C | Homo sapiens | |
2.8 | - |
Succinic semialdehyde | aldehyde reductase, mutant I298A | Homo sapiens | |
2.8 | - |
p-nitrobenzaldehyde | aldehyde reductase, mutant I298A | Homo sapiens | |
2.8 | - |
p-Carboxybenzaldehyde | aldehyde reductase, mutant H112Q | Homo sapiens | |
4.2 | - |
D-glucuronate | wild-type aldehyde reductase | Homo sapiens | |
4.2 | - |
D-glucuronate | aldehyde reductase, mutant V299C | Homo sapiens | |
5.9 | - |
p-nitrobenzaldehyde | aldehyde reductase, mutant H112Q | Homo sapiens | |
11.5 | - |
DL-glyceraldehyde | aldehyde reductase, mutant I298C | Homo sapiens | |
11.5 | - |
DL-glyceraldehyde | mutant enzyme I298C, at pH 7.0 and 25°C | Homo sapiens | |
18 | - |
Succinic semialdehyde | aldehyde reductase, mutant H112Q | Homo sapiens | |
19.5 | - |
D-glucuronate | aldehyde reductase, mutant I298C | Homo sapiens | |
26.3 | - |
D-glucuronate | aldehyde reductase, mutant I298A | Homo sapiens | |
33 | - |
DL-glyceraldehyde | aldehyde reductase, mutant I298A | Homo sapiens | |
33 | - |
DL-glyceraldehyde | mutant enzyme I298A, at pH 7.0 and 25°C | Homo sapiens | |
48 | - |
D-glucuronate | aldehyde reductase, mutant H112Q | Homo sapiens | |
76 | - |
DL-glyceraldehyde | aldehyde reductase, mutant H112Q | Homo sapiens | |
76 | - |
DL-glyceraldehyde | mutant enzyme H112Q, at pH 7.0 and 25°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
L-glyceraldehyde + NADPH | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
succinic semialdehyde + NADPH + H+ | Homo sapiens | - |
4-hydroxybutyrate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
wild-type aldehyde reductase and mutant A H112Q | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
L-glyceraldehyde + NADPH | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
p-carboxybenzaldehyde + NADPH | - |
Homo sapiens | p-carboxybenzyl alcohol + NADP+ | - |
r | |
p-nitrobenzaldehyde + NADPH | - |
Homo sapiens | p-nitrobenzylalcohol + NADP+ | - |
r | |
succinic semialdehyde + NADPH + H+ | - |
Homo sapiens | 4-hydroxybutyrate + NADP+ | - |
r |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.5 | 10 | - |
Homo sapiens |