Application | Comment | Organism |
---|---|---|
synthesis | the NADP(H)-dependent enzyme is useful in the selective chemoenzymatic synthesis of the tert-butyl (S)-6-chloro-5-hydroxy-3-ketohexanoate, a highly regio- and enantioselective reduction of a beta,delta-diketohexanoate ester, scale up of the continous fed-batch method, overview | Levilactobacillus brevis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Levilactobacillus brevis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the chemoenzymatic synthesis of the tert-butyl (S)-6-chloro-5-hydroxy-3-ketohexanoate, a highly regio- and enantioselective reduction of a beta,delta-diketohexanoate ester, is catalyzed by the enzyme. The chlorinated diketo ester is converted to the general statin precursor acetonide via the hydroxy keto ester and hydroxyhexanoate, the reaction is reversible, overview | Levilactobacillus brevis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LBADH | - |
Levilactobacillus brevis |
NADP(H)-dependent alcohol dehydrogenase | - |
Levilactobacillus brevis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | dependent on | Levilactobacillus brevis |