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Literature summary for 1.1.1.2 extracted from

  • Borzecka, W.; Lavandera, I.; Gotor, V.
    Synthesis of enantiopure fluorohydrins using alcohol dehydrogenases at high substrate concentrations (2013), J. Org. Chem., 78, 7312-7317.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Levilactobacillus brevis

Organism

Organism UniProt Comment Textmining
Levilactobacillus brevis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,2,2-trifluoro-1-phenylethanone + NADPH + H+
-
Levilactobacillus brevis (1S)-2,2,2-trifluoro-1-phenylethanol + NADP+ 99% conversion, 99% enantiomeric excess ?
2,2-difluoro-1-phenylethanone + NADPH + H+
-
Levilactobacillus brevis (1S)-2,2-difluoro-1-phenylethanol + NADP+ 99% conversion, 99% enantiomeric excess ?
2-fluoro-1-(4-chlorophenyl)ethanone + NADPH + H+
-
Levilactobacillus brevis (1S)-2-fluoro-1-(4-chlorophenyl)ethanol + NADP+ 99% conversion, 99% enantiomeric excess ?
2-fluoro-1-(4-fluorophenyl)ethanone + NADPH + H+
-
Levilactobacillus brevis (1S)-2-fluoro-1-(4-fluorophenyl)ethanol + NADP+ 99% conversion, 99% enantiomeric excess ?
2-fluoro-1-(4-iodophenyl)ethanone + NADPH + H+
-
Levilactobacillus brevis (1S)-2-fluoro-1-(4-iodophenyl)ethanol + NADP+ 99% conversion, 99% enantiomeric excess ?
2-fluoro-1-phenylethanone + NADPH + H+
-
Levilactobacillus brevis (1S)-2-fluoro-1-phenylethanol + NADP+ 99% conversion, 99% enantiomeric excess ?

Synonyms

Synonyms Comment Organism
ADH
-
Levilactobacillus brevis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Levilactobacillus brevis