Cloned (Comment) | Organism |
---|---|
- |
Agrobacterium tumefaciens |
Crystallization (Comment) | Organism |
---|---|
crystal structures of an apo-form, a ternary form in complex with NADH and product, and an inactive Y136A mutant in complex with NAD+. Enzyme is a homohexamer. The monomer contains a Rossmann fold, essential for nucleotide binding. The ternary complex structure reveals a product, D-galactaro-1,5-lactone, which is bound above the nicotinamide ring. This product rearranges in solution to D-galactaro-1,4-lactone | Agrobacterium tumefaciens |
Protein Variants | Comment | Organism |
---|---|---|
Y136A | inactive. Crystal structure shows changes in the position of residues Ile74 and Ser75. This probably alters the binding of the nicotinamide end of NAD+ | Agrobacterium tumefaciens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-galacturonate + NAD+ + H2O | Agrobacterium tumefaciens | - |
D-galactarate + NADH + H+ | - |
? | |
D-galacturonate + NAD+ + H2O | Agrobacterium tumefaciens C58 / ATCC 33970 | - |
D-galactarate + NADH + H+ | - |
? | |
D-glucuronate + NAD+ + H2O | Agrobacterium tumefaciens | - |
D-glucaric acid + NADH + H+ | - |
? | |
D-glucuronate + NAD+ + H2O | Agrobacterium tumefaciens C58 / ATCC 33970 | - |
D-glucaric acid + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agrobacterium tumefaciens | Q7CRQ0 | - |
- |
Agrobacterium tumefaciens C58 / ATCC 33970 | Q7CRQ0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-galacturonate + NAD+ + H2O | - |
Agrobacterium tumefaciens | D-galactarate + NADH + H+ | - |
? | |
D-galacturonate + NAD+ + H2O | - |
Agrobacterium tumefaciens C58 / ATCC 33970 | D-galactarate + NADH + H+ | - |
? | |
D-glucuronate + NAD+ + H2O | - |
Agrobacterium tumefaciens | D-glucaric acid + NADH + H+ | - |
? | |
D-glucuronate + NAD+ + H2O | - |
Agrobacterium tumefaciens C58 / ATCC 33970 | D-glucaric acid + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Udh | - |
Agrobacterium tumefaciens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Agrobacterium tumefaciens |