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Literature summary for 1.1.1.205 extracted from

  • Kuttan, R.; Robins, R.K.; Saunders, P.P.
    Inhibition of inosinate dehydrogenase by metabolites of 2-beta-D-ribofuranosyl thiazole-4-carboxamide (1982), Biochem. Biophys. Res. Commun., 107, 862-868.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-beta-D-ribofuranosylthiazole-4-carboxamide NSC 286193, RTC Cricetulus griseus
2-beta-D-ribofuranosylthiazole-4-carboxamide 5'-phosphate RTC monophosphate Cricetulus griseus
thiazole-4-carboxamide adenine dinucleotide inhibition is strong and not reversible by NAD+; thiazole-4-carboxamide adenine dinucleotide acts non competitive Cricetulus griseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O Cricetulus griseus the enzyme is important for the synthesis of guanine nucleotides xanthosine 5'-phosphate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification Cricetulus griseus
partially 20fold by ammonium sulfate fractionation Cricetulus griseus

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
Cricetulus griseus
-
ovary
-
Cricetulus griseus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Cricetulus griseus
0.00055
-
in cell extracts Cricetulus griseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O the enzyme is important for the synthesis of guanine nucleotides Cricetulus griseus xanthosine 5'-phosphate + NADH
-
?

Synonyms

Synonyms Comment Organism
inosinate dehydrogenase
-
Cricetulus griseus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Cricetulus griseus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Cricetulus griseus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Cricetulus griseus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000058
-
thiazole-4-carboxamide adenine dinucleotide pH 7.4, 37°C Cricetulus griseus
0.00058
-
thiazole-4-carboxamide adenine dinucleotide
-
Cricetulus griseus
0.115
-
2-beta-D-ribofuranosylthiazole-4-carboxamide 5'-phosphate pH 7.4, 37°C Cricetulus griseus