Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target in enzyme-pattern-targeted chemotherapy in acuet leukemia, AML, treatment | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NADH | mixed inhibition type versus inosine 5'-phosphate and NAD+ | Homo sapiens | |
NADH | uncompetitive versus inosine 5'-phosphate and mixed inhibition type versus NAD+ | Rattus norvegicus | |
thiazole-4-carboxamide adenine dinucleotide | i.e. TAD, mixed inhibition type versus inosine 5'-phosphate and NAD+ | Homo sapiens | |
thiazole-4-carboxamide adenine dinucleotide | i.e. TAD, uncompetitive versus inosine 5'-phosphate and mixed inhibition type versus NAD+ | Rattus norvegicus | |
tiazofurin | i.e. 2-beta-D-ribofuranosyl-thiazole-4-carboxamide, overview: clinical and molecular impact of inhibition; the drug is tested in clinical use to treat acute myelocytic leukemia, AML, detailed overview, tiazofurin treatment may result in induced differentiation of leukemic leukocytes in patients, incubation of K-562 cells with tiazofurin produces inhibition of IMP DH and decreases GTP concentration, these biochemical alterations are followed by a decrease in the expression of as proto-oncogene which is followed by induced differentiation of these cells, biochemical mechanism, overview | Homo sapiens | |
tiazofurin | inhibits cell proliferation of hepatoma cells, overview | Rattus norvegicus | |
xanthosine 5'-phosphate | competitive versus inosine 5'-phosphate but noncompetitive versus NAD+ | Homo sapiens | |
xanthosine 5'-phosphate | competitive versus inosine 5'-phosphate but noncompetitive versus NAD+ | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | Homo sapiens | rate-limiting step of the de novo guanine nucleotide biosynthesis | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | Rattus norvegicus | rate-limiting step of the de novo guanine nucleotide biosynthesis | xanthosine 5'-phosphate + NADH | - |
? | |
additional information | Homo sapiens | increased activities of IMP DH and GMP synthase and in the elevated concentrations of guanylates in hepatomas and other tumor cells | ? | - |
? | |
additional information | Rattus norvegicus | increased activities of IMP DH and GMP synthase and in the elevated concentrations of guanylates in hepatomas and other tumor cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | - |
hepatoma 3924A | - |
Purification (Comment) | Organism |
---|---|
native enzyme from hepatoma 3924A cells to homogeneity | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3924A cell | hepatoma cell line | Rattus norvegicus | - |
bone marrow | - |
Homo sapiens | - |
cell culture | - |
Homo sapiens | - |
erythroleukemia cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
hepatoma cell | - |
Rattus norvegicus | - |
HL-60 cell | leukemic cell line | Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
myelocytic leukemia cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | rate-limiting step of the de novo guanine nucleotide biosynthesis | Homo sapiens | xanthosine 5'-phosphate + NADH | - |
? | |
inosine 5'-phosphate + NAD+ + H2O | rate-limiting step of the de novo guanine nucleotide biosynthesis | Rattus norvegicus | xanthosine 5'-phosphate + NADH | - |
? | |
additional information | increased activities of IMP DH and GMP synthase and in the elevated concentrations of guanylates in hepatomas and other tumor cells | Homo sapiens | ? | - |
? | |
additional information | increased activities of IMP DH and GMP synthase and in the elevated concentrations of guanylates in hepatomas and other tumor cells | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMP DH | - |
Homo sapiens |
IMP DH | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens | |
additional information | - |
additional information | various inhibitors | Rattus norvegicus | |
additional information | - |
additional information | inhibition kinetics | Homo sapiens | |
additional information | - |
additional information | inhibition kinetics | Rattus norvegicus | |
0.00029 | - |
thiazole-4-carboxamide adenine dinucleotide | versus inosine 5'-phosphate | Homo sapiens | |
0.00031 | - |
thiazole-4-carboxamide adenine dinucleotide | versus inosine 5'-phosphate | Rattus norvegicus | |
0.00073 | - |
thiazole-4-carboxamide adenine dinucleotide | versus NAD+ | Rattus norvegicus | |
0.00074 | - |
thiazole-4-carboxamide adenine dinucleotide | versus NAD+ | Homo sapiens | |
0.118 | - |
xanthosine 5'-phosphate | versus inosine 5'-phosphate | Homo sapiens | |
0.136 | - |
xanthosine 5'-phosphate | versus inosine 5'-phosphate | Rattus norvegicus | |
0.21 | - |
NADH | versus inosine 5'-phosphate | Rattus norvegicus | |
0.23 | - |
NADH | versus inosine 5'-phosphate | Homo sapiens | |
0.28 | - |
xanthosine 5'-phosphate | versus NAD+ | Homo sapiens | |
0.287 | - |
NADH | versus NAD+ | Rattus norvegicus | |
0.32 | - |
xanthosine 5'-phosphate | versus NAD+ | Rattus norvegicus | |
0.38 | - |
NADH | versus NAD+ | Homo sapiens |