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Literature summary for 1.1.1.205 extracted from

  • Pourquie, J.
    Regulation of the biosynthesis of purine nucleotides in Schizosaccharomyces pombe. II. Kinetic studies of IMP dehydrogenase (1969), Biochim. Biophys. Acta, 185, 310-315.
    View publication on PubMed
Search for more literature for 1.1.1.205

Activating Compound

Activating Compound Comment Organism Structure
ATP 30% activation at 0.8 mM Schizosaccharomyces pombe

Inhibitors

Inhibitors Comment Organism Structure
ATP 0.8 mM, not Schizosaccharomyces pombe
CMP 25% inhibition at 0.6 mM Schizosaccharomyces pombe
GDP 45% inhibition at 0.6 mM Schizosaccharomyces pombe
GMP 55% inhibition at 0.6 mM Schizosaccharomyces pombe
GTP 45% inhibition at 0.6 mM Schizosaccharomyces pombe
TMP 25% inhibition at 0.6 mM Schizosaccharomyces pombe
UMP 25% inhibition at 0.6 mM Schizosaccharomyces pombe

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2
-
 K+
-
 Schizosaccharomyces pombe

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification Schizosaccharomyces pombe

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.008
-
-
 Schizosaccharomyces pombe

Storage Stability

Storage Stability Organism
-20°C , no appreciable loss of activity for a few weeks in 20-25% glycerol Schizosaccharomyces pombe

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
 Schizosaccharomyces pombe xanthosine 5'-phosphate + NADH
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2 9.5
-
 Schizosaccharomyces pombe

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Schizosaccharomyces pombe