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Literature summary for 1.1.1.205 extracted from

  • Magasanik, B.; Moyed, H.S.; Gehring, L.B.
    Enzymes essential for the biosynthesis of nucleic acid guanine; inosine 5'-phosphate dehydrogenase of Aerobacter aerogenes (1957), J. Biol. Chem., 226, 339-350.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cysteine cysteine or glutathione required Klebsiella aerogenes
glutathione cysteine or glutathione required Klebsiella aerogenes

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
K+ activation Klebsiella aerogenes
NH4+ activation Klebsiella aerogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O Klebsiella aerogenes obligatory step in biosynthesis of nucleic acid guanine xanthosine 5'-phosphate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Klebsiella aerogenes
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Klebsiella aerogenes

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
activity in crude extracts Klebsiella aerogenes

Storage Stability

Storage Stability Organism
-17°C no loss of activity for several months Klebsiella aerogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Klebsiella aerogenes xanthosine 5'-phosphate + NADH
-
ir
inosine 5'-phosphate + NAD+ + H2O obligatory step in biosynthesis of nucleic acid guanine Klebsiella aerogenes xanthosine 5'-phosphate + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Klebsiella aerogenes