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Literature summary for 1.1.1.209 extracted from

  • Nakagawa, M.; Tsukuda, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.
    Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydoxysteroid dehydrogenase activity in mouse kidney (1989), J. Biochem., 106, 633-638.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
17beta-estradiol 5 mM, 77% inhibition Mus musculus
5alpha-Androstan-3beta-ol-17-one 1 mM, 80% inhibition Mus musculus
5alpha-pregnan-3beta-ol-21-one 1 mM, 66% inhibition Mus musculus
5beta-androstan-3beta-ol-17-one 1 mM, 91% inhibition Mus musculus
5beta-Pregnan-3beta-ol-20-one 1 mM, 80% inhibition Mus musculus
Barbital 100 mM, 11% inhibition Mus musculus
Dienstrol 1 mM, 22% inhibition Mus musculus
Hexestrol 1 mM, 77% inhibition Mus musculus
Stilbestrol 10 mM, 75% inhibition Mus musculus
testosterone 1 mM, 48% inhibition Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0001
-
Epitestosterone cofactor NADP+ Mus musculus
0.0001
-
5beta-androstane-3alpha,17beta-diol cofactor NADP+ Mus musculus
0.0003
-
5beta-androstane-3alpha,17beta-diol cofactor NADP+ Mus musculus
0.0004
-
glycolithocholic acid cofactor NADP+ Mus musculus
0.0005
-
5beta-pregnane-3alpha,20alpha-diol cofactor NADP+ Mus musculus
0.0007
-
5beta-pregnane-3alpha-ol-20-one cofactor NADP+ Mus musculus
0.004
-
NADP+
-
Mus musculus
0.16
-
(R)-1-indanol cofactor NADP+ Mus musculus
0.26
-
NAD+
-
Mus musculus
0.77
-
trans-benzene dihydrodiol cofactor NADP+ Mus musculus
1.99
-
cis-benzene dihydrodiol cofactor NADP+ Mus musculus
2.23
-
cyclohex-2-ene-1-ol cofactor NADP+ Mus musculus
2.67
-
Naphthalene dihydrodiol cofactor NADP+ Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
gel filtration Mus musculus
39000
-
1 * 39000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Q-Sepharose, Matrex Red A, HA-Ultrogel, Sephadex G-100, two enzyme preparations DD1 and DD2 with almost identical properties, products of post-translational or post-mortem modification rather than isoenzymes Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.27
-
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-1-indanol + NADP+ 37% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 1-indanone + NADPH
-
?
(S)-1-indanole + NADP+ 7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 1-indanone + NADPH
-
?
1-acenaphthenol + NADP+ 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 1-acenaphthenone + NADPH
-
?
4-nitrobenzaldehyde + NADPH 58% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 4-nitrobenzyl alcohol + NADP+
-
?
5alpha-androstane-3alpha,17beta-diol + NADP+ 7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5alpha-androstane-17beta-ol-3-one + NADPH
-
?
5alpha-pregnan-3alpha,20alpha-diol + NADP+ 6% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5alpha-pregnan-20alpha-ol-3-one + NADPH
-
?
5alpha-pregnan-3alpha,21-diol-20-one + NADP+ 7% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5alpha-pregnan-21alpha-ol-3,20-dione + NADPH
-
?
5alpha-pregnane-21-ol-3,20-dione + NADPH 75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5beta-pregnane-3alpha,21-diol-20-one + NADP+
-
?
5alpha-pregnane-3,20-dione + NADPH 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5alpha-pregnane-3alpha-ol-20-one + NADP+
-
?
5beta-androstan-17beta-ol-3-one + NADPH 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5beta-androstan-17beta,3alpha-diol + NADP+
-
?
5beta-androstane-3,17-dione + NADPH 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5beta-androstan-3alpha-ol-17-one + NADP+
-
?
5beta-androstane-3alpha,17beta-diol + NADP+ 11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5beta-androstane-17beta-ol-3-one + NADPH
-
?
5beta-androstane-3alpha-ol-17-one + NADP+ 9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5beta-androstane-3,17-dione + NADPH
-
?
5beta-pregnan-3alpha,20alpha-diol + NADP+ 26% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5beta-pregnan-3-one-20alpha-ol + NADPH
-
?
5beta-pregnan-3alpha-ol-20-one + NADP+ 19% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5beta-pregnan-3,20-dione + NADPH
-
?
5beta-pregnane-3,20-dione + NADPH + H+ 21% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 5beta-pregnane-3alpha-ol-20-one + NADP+
-
?
acenaphthenequinone + NADPH 44% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus acenaphthenehydroquinone + NADP+
-
?
androst-4-ene-3,17-dione + NADPH 10% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus androst-4-ene-3alpha-ol-17-one + NADP+
-
?
camphorquinone + NADPH + H+ 52% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus camphorhydroquinone + NADP+
-
?
cis-1,2-dihydroxy-3,5-cyclohexadiene + NADP+ 60% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus catechol + NADPH
-
?
cyclohex-2-ene-1-ol + NADP+ 9% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus cyclohex-2-en-1-one + NADPH
-
?
cyclohexanone + NADPH 16% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus cyclohexanol + NADP+
-
?
epitestosterone + NADP+ 11% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus testosterone + NADPH + H+
-
?
glycolithocholic acid + NADP+ 56% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus N-[(5beta)-3,24-dioxocholan-24-yl]glycine + NADPH
-
?
naphthalene dihydrodiol + NADP+ 49% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus naphthacatechol + NADPH
-
?
pyridine-4-ol + NADP+ 75% of activity with trans-1,2-dihydroxy-3,5-cyclohexadiene Mus musculus 3H-pyridine-4-one + NADPH
-
?
tetrahydrodeoxycorticosterone + NAD+
-
Mus musculus ?
-
r
trans-1,2-dihydroxy-3,5-cyclohexadiene + NADP+
-
Mus musculus catechol + NADPH
-
?

Subunits

Subunits Comment Organism
monomer 1 * 39000, SDS-PAGE Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.8 5beta-pregnane-3,20-dione as substrate, cofactor NADPH Mus musculus