Cloned (Comment) | Organism |
---|---|
overexpression of the enzyme in lens epithelial cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme overexpression prevents the lipid aldehyde-induced activation of caspase-3, p38 MAPK, JNK, and the expression of Bcl-2 family proteins in lens epithelial cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sorbinil | in vivo inhibition potentiates apoptosis due to lipid aldehydes, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | Homo sapiens | the enzyme prevents lipid aldehyde-induced cytotoxicity leading to apoptosis in cultured lens epithelial cells, effects of diverse saturated and unsaturated aldehydes, overview | alditol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | from lens | Homo sapiens | - |
lens | cultured epithelial cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | - |
Homo sapiens | alditol + NADP+ | - |
? | |
aldose + NADPH + H+ | the enzyme prevents lipid aldehyde-induced cytotoxicity leading to apoptosis in cultured lens epithelial cells, effects of diverse saturated and unsaturated aldehydes, overview | Homo sapiens | alditol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |