Application | Comment | Organism |
---|---|---|
medicine | inhibition of AR may be a significant therapeutic approach in preventing bacterial endotoxin-induced sepsis and tissue damage | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of the aldehyde-metabolizing enzyme modulates NF-kappaB-dependent activation of inflammatory cytokines and chemokines in mouse serum, liver, heart, and spleen, overview | Mus musculus | |
sorbinil | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | Mus musculus | the enzyme mediates the lipopolysaccharide-induced release of inflammatory mediators in macrophages, overview, inhibition of the aldehyde-metabolizing enzyme modulates NF-kappaB-dependent activation of inflammatory cytokines and chemokines in mouse serum, liver, heart, and spleen, overview | alditol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Mus musculus | - |
RAW-264.7 cell | macrophage cell line | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | - |
Mus musculus | alditol + NADP+ | - |
? | |
aldose + NADPH + H+ | the enzyme mediates the lipopolysaccharide-induced release of inflammatory mediators in macrophages, overview, inhibition of the aldehyde-metabolizing enzyme modulates NF-kappaB-dependent activation of inflammatory cytokines and chemokines in mouse serum, liver, heart, and spleen, overview | Mus musculus | alditol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AKR1B3 | - |
Mus musculus |
aldose reductase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus |