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Literature summary for 1.1.1.21 extracted from
- Novel aldose reductase inhibitors derived from 6-[[(diphenylmethylene)amino]oxy]hexanoic acid (2007), Arch. Pharm., 340, 202-208.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-[[(di(2,4-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid | - |
Homo sapiens |  |
| 6-[[(di(3,5-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid | - |
Homo sapiens | |
| 6-[[(di(4-methoxy-3-methylphenyl)methylidene)amino]oxy]hexanoic acid | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DL-glyceraldehyde + NAD(P)H | - |
Homo sapiens | glycerol + NAD(P)+ | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00292 | - |
6-[[(di(4-methoxy-3-methylphenyl)methylidene)amino]oxy]hexanoic acid | pH 6.8, 37°C | Homo sapiens | |
| 0.00297 | - |
6-[[(di(2,4-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid | pH 6.8, 37°C | Homo sapiens | |
| 0.00299 | - |
6-[[(di(3,5-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid | pH 6.8, 37°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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