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Literature summary for 1.1.1.21 extracted from

  • Wang, S.; Yan, J.; Hao, D.; Niu, X.; Cheng, M.
    Synthesis and activity of a new series of (Z)-3-phenyl-2-benzoylpropenoic acid derivatives as aldose reductase inhibitors (2007), Molecules, 12, 885-895.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular modeling of complex with NADP+ and inhibitor (2Z)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2Z)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid
-
Rattus norvegicus
(2Z)-3-(3-methoxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid
-
Rattus norvegicus
epalrestat
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens P15121
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH
-
Rattus norvegicus glycerol + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000075
-
37°C, pH 7.0 Rattus norvegicus epalrestat
0.00049
-
37°C, pH 7.0 Rattus norvegicus (2Z)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid
0.00795
-
37°C, pH 7.0 Rattus norvegicus (2Z)-3-(3-methoxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid