Application | Comment | Organism |
---|---|---|
medicine | inhibition of aldose reductase may represent a useful strategy for treating vascular inflammation associated with diabetes | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sorbinil | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor-alpha via protein kinase C-delta and tumor necrosis factor-alpha converting enzyme in vascular smooth muscle cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular smooth muscle cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor-alpha via protein kinase C-delta and tumor necrosis factor-alpha converting enzyme in vascular smooth muscle cells | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |