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Literature summary for 1.1.1.21 extracted from

  • Ramana, K.V.; Tammali, R.; Srivastava, S.K.
    Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells (2010), Mol. Cancer Ther., 9, 813-824.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
fidarestat
-
Homo sapiens
additional information inhibition of the enzyme activity also inhibits the expression of the enzyme protein in xenograft tissue Homo sapiens
sorbinil
-
Homo sapiens
zopolrestat
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DL-glyceraldehyde + NADPH + H+ Homo sapiens
-
DL-glycerol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-
SW-480 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
Homo sapiens DL-glycerol + NADP+
-
?

Synonyms

Synonyms Comment Organism
aldose reductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens inhibition of the enzyme activity also inhibits the expression of the enzyme protein in xenograft tissue down

General Information

General Information Comment Organism
physiological function inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in colon cancer cells. Inhibition of aldose reductasee prevents EGF- and bFGF-induced DNA binding activity and expression of E2F-1 in colon cancer cells, overview Homo sapiens