Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-4-oxo-3,4-dihydropteridine-6-carboxylic acid | - |
Homo sapiens | |
2-amino-4-oxo-3,4-dihydropteridine-7-carboxylic acid | - |
Homo sapiens | |
2-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]-4-phenylbutanoic acid | - |
Homo sapiens | |
4-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]butanoic acid | - |
Homo sapiens | |
5-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]pentanoic acid | - |
Homo sapiens | |
6-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]hexanoic acid | - |
Homo sapiens | |
epalrestat | - |
Homo sapiens | |
folic acid | - |
Homo sapiens | |
additional information | analysis of pterin-7-carboxamides as aldose reductase inhibitors, evaluation of the inhibitory activity of the compounds | Homo sapiens | |
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-beta-alanine | - |
Homo sapiens | |
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-alanine | - |
Homo sapiens | |
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-isoleucine | - |
Homo sapiens | |
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-leucine | - |
Homo sapiens | |
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-phenylalanine | - |
Homo sapiens | |
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-serine | - |
Homo sapiens | |
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-tyrosine | - |
Homo sapiens | |
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-valine | - |
Homo sapiens | |
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycine | - |
Homo sapiens | |
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanine | 9% inhibition at 10.5 mM | Homo sapiens | |
sorbinil | - |
Homo sapiens | |
[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino](phenyl)acetic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15121 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
AKR1B1 | gene name, UniProt | Homo sapiens |
aldose reductase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000665 | - |
pH and temperature not specified in the publication | Homo sapiens | epalrestat | |
0.00197 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycine | |
0.00402 | - |
pH and temperature not specified in the publication | Homo sapiens | 6-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]hexanoic acid | |
0.0117 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]pentanoic acid | |
0.0124 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-alanine | |
0.0175 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-beta-alanine | |
0.0251 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]-4-phenylbutanoic acid | |
0.0255 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]butanoic acid | |
0.0265 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-amino-4-oxo-3,4-dihydropteridine-7-carboxylic acid | |
0.0292 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-serine | |
0.0426 | - |
pH and temperature not specified in the publication | Homo sapiens | [(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino](phenyl)acetic acid | |
0.046 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-phenylalanine | |
0.0525 | - |
pH and temperature not specified in the publication | Homo sapiens | folic acid | |
0.0617 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-leucine | |
0.069 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-isoleucine | |
0.0834 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-valine | |
0.216 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-tyrosine |