Any feedback?
Literature summary for 1.1.1.213 extracted from
- Multiplicity of mammalian reductases for xenobiotic carbonyl compounds (2006), Drug Metab. Pharmacokinet., 21, 1-18.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| chromosomal localization is 10q15-q14, phylogenetic tree | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-oxonortriptyline + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? |  |
| 3-ketosteroids + NADPH | Homo sapiens | - |
3-hydroxysteroids + NADP+ | - |
? | |
| 5alpha-dihydrotestosterone + NADPH | Homo sapiens | the enzyme is important in inactivation of DHT | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
? | |
| acetohexamide + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| befunolol + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| daunorubicin + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| dolasetron + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| haloperidol + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| ketoprofen + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| ketotifen + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| loxoprofen + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| additional information | Homo sapiens | the enzyme is important in the synthesis of neuroactive 5alpha/beta-pregnan-3alpha-ol-20-ones from their precursors, the enzyme plays a role in development and progression of prostate cancer | ? | - |
? | |
| Naloxone + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| Naltrexone + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| oracin + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| oxycodone + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P52895 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | the enzyme expression is positively correlated to adiposity in woman | Homo sapiens | - |
| astrocyte | high expression and activity in astrocytes of glaucomatous optic nerve head | Homo sapiens | - |
| additional information | wide tissue distribution | Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-oxonortriptyline + NADPH | - |
Homo sapiens | ? | - |
? | |
| 10-oxonortriptyline + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 3-ketosteroids + NADPH | - |
Homo sapiens | 3-hydroxysteroids + NADP+ | - |
? | |
| 5alpha-dihydrotestosterone + NADPH | the enzyme is important in inactivation of DHT | Homo sapiens | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
? | |
| 5alpha-dihydrotestosterone + NADPH | i.e. DHT | Homo sapiens | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
? | |
| acetohexamide + NADPH | - |
Homo sapiens | ? | - |
? | |
| acetohexamide + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| befunolol + NADPH | - |
Homo sapiens | ? | - |
? | |
| befunolol + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| daunorubicin + NADPH | - |
Homo sapiens | ? | - |
? | |
| daunorubicin + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| dolasetron + NADPH | - |
Homo sapiens | ? | - |
? | |
| dolasetron + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| haloperidol + NADPH | - |
Homo sapiens | ? | - |
? | |
| haloperidol + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| ketoprofen + NADPH | - |
Homo sapiens | ? | - |
? | |
| ketoprofen + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| ketotifen + NADPH | - |
Homo sapiens | ? | - |
? | |
| ketotifen + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| loxoprofen + NADPH | - |
Homo sapiens | ? | - |
? | |
| loxoprofen + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is important in the synthesis of neuroactive 5alpha/beta-pregnan-3alpha-ol-20-ones from their precursors, the enzyme plays a role in development and progression of prostate cancer | Homo sapiens | ? | - |
? | |
| Naloxone + NADPH | - |
Homo sapiens | ? | - |
? | |
| Naloxone + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| Naltrexone + NADPH | - |
Homo sapiens | ? | - |
? | |
| Naltrexone + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| oracin + NADPH | - |
Homo sapiens | ? | - |
? | |
| oracin + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| oxycodone + NADPH | - |
Homo sapiens | ? | - |
? | |
| oxycodone + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3alpha-HSD type 3 | - |
Homo sapiens |
| AKR1C2 | - |
Homo sapiens |
| bile acid-binding protein | - |
Homo sapiens |
| DD2 | - |
Homo sapiens |
| More | the enzyme is a member of the aldo-keto reductase family | Homo sapiens |
| type 3 3-alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
