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Literature summary for 1.1.1.22 extracted from

  • Hung, R.J.; Chien, H.S.; Lin, R.Z.; Lin, C.T.; Vatsyayan, J.; Peng, H.L.; Chang, H.Y.
    Comparative analysis of two UDP-glucose dehydrogenases in Pseudomonas aeruginosa PAO1 (2007), J. Biol. Chem., 282, 17738-17748.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pseudomonas aeruginosa

Protein Variants

Protein Variants Comment Organism
additional information mutant lacking PA2022 activity and double mutant lacking PA2022 and isoform PA3559 activity are more susceptible to chloramphenicol, ceffotaxime, and ampicillin Pseudomonas aeruginosa
additional information mutant lacking PA3559 activity shows reduced resistance to polymyxin B Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ 84% residual activity at 1 mM Pseudomonas aeruginosa
EDTA 83% residual activity at 1 mM Pseudomonas aeruginosa
Mn2+ 84% residual activity at 1 mM Pseudomonas aeruginosa
NADH product inhibition, 26% residual activity at 0.05 mM; product inhibition, 70% residual activity at 0.05 mM Pseudomonas aeruginosa
UDP-glucuronic acid product inhibition, 44% residual activity at 1 mM; product inhibition, 79% residual activity at 1 mM Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
UDP-glucose pH 7.5, 22°C Pseudomonas aeruginosa
0.4
-
UDP-glucose pH 7.5, 22°C Pseudomonas aeruginosa
0.47
-
NAD+ pH 7.5, 22°C Pseudomonas aeruginosa
1.99
-
NAD+ pH 7.5, 22°C Pseudomonas aeruginosa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54500
-
54500, calculated Pseudomonas aeruginosa
57400
-
57400, calculated Pseudomonas aeruginosa
104000
-
gel filtration Pseudomonas aeruginosa
117000
-
gel filtration Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa O86422 isoform PA2022, constitutively expressed
-
Pseudomonas aeruginosa Q9HY58 isoform PA3559, expressed primarily in low concentrations of Mg2+
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
TDP-glucose + NAD+ + H2O 38.5% of the rate with UDP-glucose Pseudomonas aeruginosa TDP-glucuronate + NADH
-
?
UDP-galactose + NAD+ + H2O 11.9% of the rate with UDP-glucose Pseudomonas aeruginosa UDP-galacturonate + NADH
-
?
UDP-galactose + NAD+ + H2O 6.4% of the rate with UDP-glucose Pseudomonas aeruginosa UDP-galacturonate + NADH
-
?
UDP-glucose + 2 NAD+ + H2O
-
Pseudomonas aeruginosa UDP-glucuronate + 2 NADH + 2 H+
-
?
UDP-N-acetylglucosamine + NAD+ + H2O 35% of the rate with UDP-glucose Pseudomonas aeruginosa ? + NADH
-
?
UDP-N-acetylglucosamine + NAD+ + H2O 6.3% of the rate with UDP-glucose Pseudomonas aeruginosa ? + NADH
-
?

Subunits

Subunits Comment Organism
dimer 54500, calculated Pseudomonas aeruginosa
dimer 57400, calculated Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
PA2022
-
Pseudomonas aeruginosa
PA3559
-
Pseudomonas aeruginosa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.24
-
UDP-glucose pH 7.5, 22°C Pseudomonas aeruginosa
0.37
-
NAD+ pH 7.5, 22°C Pseudomonas aeruginosa
0.81
-
UDP-glucose pH 7.5, 22°C Pseudomonas aeruginosa
2.35
-
NAD+ pH 7.5, 22°C Pseudomonas aeruginosa