Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
x * 42000, SDS-PAGE, x * 43400, calculated | Streptococcus pyogenes |
43400 | - |
x * 42000, SDS-PAGE, x * 43400, calculated | Streptococcus pyogenes |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pyogenes | Q9A0Z5 | isoform HasB2 | - |
Streptococcus pyogenes 5448 | Q9A0Z5 | isoform HasB2 | - |
Streptococcus pyogenes M1 GAS | P0C0F5 | isoform HasB | - |
Streptococcus pyogenes M1 GAS 5448 | P0C0F5 | isoform HasB | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-glucose + 2 NAD+ + H2O | - |
Streptococcus pyogenes | UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | - |
? | |
UDP-alpha-D-glucose + 2 NAD+ + H2O | - |
Streptococcus pyogenes 5448 | UDP-alpha-D-glucuronate + 2 NADH + 2 H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 42000, SDS-PAGE, x * 43400, calculated | Streptococcus pyogenes |
Synonyms | Comment | Organism |
---|---|---|
HasB | - |
Streptococcus pyogenes M1 GAS |
HasB2 | - |
Streptococcus pyogenes |
General Information | Comment | Organism |
---|---|---|
physiological function | precise allelic exchange mutagenesis of isoform hasB in strain 5448, a representative of the globally disseminated M1T1 serotype, does not abolish hyaluronic acid capsule synthesis due to presence of paralog HasB2. Mutagenesis of HasB2 alone slightly decreases capsule abundance. A HasB HasB2 double mutant becomes completely acapsular | Streptococcus pyogenes M1 GAS |
physiological function | precise allelic exchange mutagenesis of isoform hasB in strain 5448, a representative of the globally disseminated M1T1 serotype, does not abolish hyaluronic acid capsule synthesis due to presence of paralog HasB2. Mutagenesis of HasB2 alone slightly decreases capsule abundance. A HasB HasB2 double mutant becomes completely acapsular | Streptococcus pyogenes |