Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3S)-3-amino-1-[4-(benzyloxy)phenyl]-4-(1H-imidazol-4-yl)butan-2-one | - |
Brucella suis | |
(3S)-3-amino-1-[4-(biphenyl-4-ylethynyl)phenyl]-4-(1H-imidazol-4-yl)butan-2-one | - |
Brucella suis | |
(3S)-3-amino-1-[4-(biphenyl-4-ylmethoxy)phenyl]-4-(1H-imidazol-4-yl)butan-2-one | - |
Brucella suis | |
(3S)-3-amino-1-[4-[(4-bromobenzyl)oxy]phenyl]-4-(1H-imidazol-4-yl)butan-2-one | - |
Brucella suis | |
(3S)-3-amino-1-[4-[(4-butylbenzyl)oxy]phenyl]-4-(1H-imidazol-4-yl)butan-2-one | 50% inhibition of pathogen growth in minimal medium at 0.5 mM | Brucella suis | |
(3S)-3-amino-1-[4-[(4-tert-butylphenyl)ethynyl]phenyl]-4-(1H-imidazol-4-yl)butan-2-one | 30% inhibition of pathogen growth in minimal medium at 0.5 mM | Brucella suis | |
(3S)-3-amino-1-[4-[(E)-2-(biphenyl-4-yl)ethenyl]phenyl]-4-(1H-imidazol-4-yl)butan-2-one | - |
Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]phenyl)butan-2-one | - |
Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[[4-(naphthalen-2-yl)benzyl]oxy]phenyl)butan-2-one | complete inhibition of pathogen growth in minimal medium at 0.5 mM | Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[[4-(trifluoromethyl)benzyl]oxy]phenyl)butan-2-one | 70% inhibition of pathogen growth in minimal medium at 0.5 mM | Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-(2-phenylethyl)phenyl]butan-2-one | - |
Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-(phenylethynyl)phenyl]butan-2-one | complete inhibition of pathogen growth in minimal medium at 0.5 mM | Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(1E)-3-phenylprop-1-en-1-yl]phenyl]butan-2-one | - |
Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methoxybenzyl)oxy]phenyl]butan-2-one | 30% inhibition of pathogen growth in minimal medium at 0.5 mM | Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methylbenzyl)oxy]phenyl]butan-2-one | 30% inhibition of pathogen growth in minimal medium at 0.5 mM | Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methylphenyl)ethynyl]phenyl]butan-2-one | - |
Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-pentylphenyl)ethynyl]phenyl]butan-2-one | 30% inhibition of pathogen growth in minimal medium at 0.5 mM | Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-phenoxybenzyl)oxy]phenyl]butan-2-one | 70% inhibition of pathogen growth in minimal medium at 0.5 mM | Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(E)-2-(4-methylphenyl)ethenyl]phenyl]butan-2-one | complete inhibition of pathogen growth in minimal medium at 0.5 mM | Brucella suis | |
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(E)-2-phenylethenyl]phenyl]butan-2-one | - |
Brucella suis | |
additional information | design, synthesis and evaluation of 19 potential HDH inhibitors, molecular modeling and docking study, overview | Brucella suis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidinol + 2 NAD+ + H2O | Brucella suis | - |
L-histidine + 2 NADH + 3 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Brucella suis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidinol + 2 NAD+ + H2O | - |
Brucella suis | L-histidine + 2 NADH + 3 H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDH | - |
Brucella suis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Brucella suis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
3 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-1-[4-(benzyloxy)phenyl]-4-(1H-imidazol-4-yl)butan-2-one | |
3 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-(phenylethynyl)phenyl]butan-2-one | |
8.5 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-pentylphenyl)ethynyl]phenyl]butan-2-one | |
13 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-(2-phenylethyl)phenyl]butan-2-one | |
20 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methoxybenzyl)oxy]phenyl]butan-2-one | |
25 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(E)-2-phenylethenyl]phenyl]butan-2-one | |
30 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methylbenzyl)oxy]phenyl]butan-2-one | |
30 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[[4-(trifluoromethyl)benzyl]oxy]phenyl)butan-2-one | |
30 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[[4-(naphthalen-2-yl)benzyl]oxy]phenyl)butan-2-one | |
30 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(1E)-3-phenylprop-1-en-1-yl]phenyl]butan-2-one | |
40 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-1-[4-[(4-butylbenzyl)oxy]phenyl]-4-(1H-imidazol-4-yl)butan-2-one | |
40 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(E)-2-(4-methylphenyl)ethenyl]phenyl]butan-2-one | |
40 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methylphenyl)ethynyl]phenyl]butan-2-one | |
65 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]phenyl)butan-2-one | |
65 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-1-[4-[(4-tert-butylphenyl)ethynyl]phenyl]-4-(1H-imidazol-4-yl)butan-2-one | |
70 | - |
pH and temperature not specified in the publication | Brucella suis | (3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-phenoxybenzyl)oxy]phenyl]butan-2-one |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition leads to inhibition of intracellular bacterial growth in macrophage infection of the facultative intracellular pathogen | Brucella suis |
metabolism | the enzyme catalyzes the last step in histidine biosynthesis | Brucella suis |
physiological function | the enzyme is essential for intramacrophagic replication | Brucella suis |