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Literature summary for 1.1.1.234 extracted from

  • Mizuno, H.; Yazawa, T.; Kasuga, S.; Sawada, Y.; Kanamori, H.; Ogo, Y.; Hirai, M.Y.; Matsumoto, T.; Kawahigashi, H.
    Expression of flavone synthase II and flavonoid 3'-hydroxylase is associated with color variation in tan-colored injured leaves of Sorghum (2016), Front. Plant Sci., 7, 1718.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene P or Sb06g029550, genetic structure, quantitative RT-PCR enzyme expression analysis Sorghum bicolor

Protein Variants

Protein Variants Comment Organism
additional information expression of both flavone synthase II (FNSII) and flavonoid 3'-hydroxylase (F3'H) leads to the synthesis of apigenin and luteolin in cultivar #7, and expression of both flavanone 4-reductase and F3'H leads to the synthesis of 3-deoxyanthocyanidins in cultivar Nakei-MS3B Sorghum bicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2S)-flavan-4-ol + NADP+ Sorghum bicolor
-
 (2S)-flavanone + NADPH + H+
-
 ?
eriodictyol + NADP+ Sorghum bicolor
-
 luteoforol + NADPH + H+
-
 ?
naringenin + NADPH + H+ Sorghum bicolor
-
 apiforol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Sorghum bicolor C5YGL7 cultivars #7, M36001, and Nakei
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Sorghum bicolor
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S)-flavan-4-ol + NADP+
-
 Sorghum bicolor (2S)-flavanone + NADPH + H+
-
 ?
eriodictyol + NADP+
-
 Sorghum bicolor luteoforol + NADPH + H+
-
 ?
additional information enzyme FNR converts flavanones to flavan-4-ols Sorghum bicolor ?
-
 ?
naringenin + NADPH + H+
-
 Sorghum bicolor apiforol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
3-deoxyanthocyanidin synthase
-
 Sorghum bicolor
FNR
-
 Sorghum bicolor
Sb06g029550
-
 Sorghum bicolor

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Sorghum bicolor

Expression

Organism Comment Expression
Sorghum bicolor the enzyme is highly induced by cutting stress up

General Information

General Information Comment Organism
malfunction Sorghums with a tan injury response have non-functional FNR alleles (p). The FNR gene of cultivar M36001 has an insertion in the coding region. Sorghums with a tan injury response have lower levels of flavan-4-ols (precursors of apigeninidin and luteolinidin-apiforol and luteoforol, respectively) than do sorghums with a purple or red injury response and are unable to synthesize 3-deoxyanthocyanidins Sorghum bicolor
physiological function the enzyme is responsible for the synthesis of 3-deoxyanthocyanidins. The variation of purple-red-orange is explained by the balance of two 3-deoxyanthocyanidins, uteolinidin and apigeninidin. The balance is controlled by the expression level of flavonoid 3'-hydroxylase (F3'H), which encodes a protein that hydroxylates the 3' position of the B-ring of naringenin to produce a precursor of luteolinidin Sorghum bicolor