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Literature summary for 1.1.1.237 extracted from

  • Häusler, E.; Petersen, M.; Alfermann, A.W.
    Hydroxyphenylpyruvate reductase from cell suspension cultures of Coleus blumei Benth (1991), Z. Naturforsch. C, 46, 371-376.
No PubMed abstract available
Search for more literature for 1.1.1.237

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxyphenylpyruvate substrate inhibition Coleus scutellarioides
dihydroxyphenylpyruvate substrate inhibition Coleus scutellarioides
p-Coumaroyl-CoA 50% inhibition at 0.5 mM Coleus scutellarioides
pyruvate competitive inhibition Coleus scutellarioides
rosmarinic acid competitive inhibition Coleus scutellarioides

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
10
-
 4-hydroxyphenylpyruvate pH 7 Coleus scutellarioides
95
-
 NADPH pH 7 Coleus scutellarioides
130
-
 3,4-Dihydroxyphenylpyruvate pH 7 Coleus scutellarioides
190
-
 NADH pH 7 Coleus scutellarioides
250
-
 3-methoxy-4-hydroxyphenylpyruvate pH 7 Coleus scutellarioides

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-(4-hydroxyphenyl)lactate + NAD+ Coleus scutellarioides
-
 4-hydroxyphenylpyruvate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Coleus scutellarioides
-
-
-

Storage Stability

Storage Stability Organism
-20°C, loss of 30% activity after 1 month Coleus scutellarioides
-20°C, loss of 85% activity after 10 weeks Coleus scutellarioides

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenylpyruvate + NADH + H+
-
 Coleus scutellarioides 3-(3,4-dihydroxyphenyl)lactate + NAD+
-
 r
3-(4-hydroxyphenyl)lactate + NAD+
-
 Coleus scutellarioides 4-hydroxyphenylpyruvate + NADH + H+
-
 ?
3-methoxy-4-hydroxyphenylpyruvate + NADH + H+
-
 Coleus scutellarioides 3-(3-methoxy-4-hydroxyphenyl)lactate + NAD+
-
 ?
4-hydroxyphenylpyruvate + NADH + H+
-
 Coleus scutellarioides 3-(4-hydroxyphenyl)lactate + NAD+
-
 r
beta-phenylpyruvate + NADH + H+
-
 Coleus scutellarioides 2-hydroxy-3-phenylpropanoate + NAD+
-
 r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35 37
-
 Coleus scutellarioides

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7
-
 Coleus scutellarioides