Inhibitors | Comment | Organism | Structure |
---|---|---|---|
21-hydroxypregn-4-ene-3,20-dione | 0.010 mM, 73% inhibition | Mesocricetus auratus | |
5alpha-Androstan-3beta-ol-17-one | 0.005 mM, 55% inhibition | Mesocricetus auratus | |
5alpha-pregnan-3beta-ol-20-one | 0.005 mM, 52% inhibition | Mesocricetus auratus | |
5beta-androstan-3beta-ol-17-one | 0.005 mM, 87% inhibition | Mesocricetus auratus | |
5beta-Pregnan-3beta-ol-20-one | 0.005 mM, 81% inhibition | Mesocricetus auratus | |
dexamethasone | 0.10 mM, 39% inhibition | Mesocricetus auratus | |
Dienstrol | 0.010 mM, 60% inhibition | Mesocricetus auratus | |
Hexoestrol | 0.010 mM, 62% inhibition | Mesocricetus auratus | |
indomethacin | 0.10 mM, 67% inhibition | Mesocricetus auratus | |
Medroxyprogesterone acetate | 0.010 mM, 22% inhibition | Mesocricetus auratus | |
stilboestrol | 0.010 mM, 61% inhibition | Mesocricetus auratus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
lithocholic acid | - |
Mesocricetus auratus | |
0.0022 | - |
testosterone | - |
Mesocricetus auratus | |
0.003 | - |
glycolithocholic acid | - |
Mesocricetus auratus | |
0.0031 | - |
5alpha-androstan-3alpha,17beta-diol | - |
Mesocricetus auratus | |
0.0038 | - |
5beta-pregnan-3,20-dione | - |
Mesocricetus auratus | |
0.0046 | - |
5beta-Pregnan-3alpha-ol-20-one | - |
Mesocricetus auratus | |
0.0048 | - |
5beta-Androstan-3alpha,17beta-diol | - |
Mesocricetus auratus | |
0.0049 | - |
5beta-androstan-17beta-ol-3-one | - |
Mesocricetus auratus | |
0.0062 | - |
5beta-pregnan-3alpha,17beta-diol-20-one | - |
Mesocricetus auratus | |
0.0066 | - |
5beta-androstan-3,17-dione | - |
Mesocricetus auratus | |
0.0075 | - |
glycochenodeoxycholic acid | - |
Mesocricetus auratus | |
0.02 | - |
NADH | - |
Mesocricetus auratus | |
0.27 | - |
NAD+ | - |
Mesocricetus auratus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mesocricetus auratus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mesocricetus auratus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mesocricetus auratus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
4.2 | - |
- |
Mesocricetus auratus |
Storage Stability | Organism |
---|---|
4°C, 10 mM Tris/HCl buffer, pH 8.0, 5 mM 2-mercaptoethanol, 0.5 mM EDTA | Mesocricetus auratus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-androstan-3alpha,17beta-diol + NAD+ | - |
Mesocricetus auratus | 5alpha-androstan-3alpha-ol-17-one + NADH | - |
? | |
5alpha-pregnan-3,21alpha-diol-20-one + NAD+ | - |
Mesocricetus auratus | 5alpha-pregnan-21-ol-3,20-dione + NADH | - |
? | |
5beta-androstan-17beta-ol-3-one + NAD+ | - |
Mesocricetus auratus | 5beta-androstan-3,17-dione + NADH | - |
? | |
5beta-androstan-3alpha,17beta-diol + NAD+ | - |
Mesocricetus auratus | 5beta-androstan-3alpha-ol-17-one + NADH | - |
? | |
5beta-pregnan-3alpha,21-diol-20-one + NAD+ | - |
Mesocricetus auratus | 5beta-pregnan-21-ol-3,20-dione + NADH | - |
? | |
5beta-pregnan-3alpha-ol-20-one + NAD+ | - |
Mesocricetus auratus | 5beta-pregnan-3,20-dione + NADH | - |
? | |
glycochenodeoxycholic acid + NAD+ | - |
Mesocricetus auratus | 7alpha-hydroxy-3-oxo-5-beta-cholanoyl glycine + NADH | - |
? | |
glycolithocholic acid + NAD+ | - |
Mesocricetus auratus | 3-oxo-5beta-cholanoyl glycine + NADH | - |
? | |
lithocholic acid + NAD+ | - |
Mesocricetus auratus | 5beta-cholan-3-one-24-oic acid + NADH | - |
? | |
testosterone + NAD+ | - |
Mesocricetus auratus | androst-4-ene-3,17-dione + NADH + H+ | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | - |
half-life 2.3 min | Mesocricetus auratus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
glycochenodeoxycholic acid | - |
Mesocricetus auratus | |
0.05 | - |
lithocholic acid | - |
Mesocricetus auratus | |
0.158 | - |
5beta-pregnan-3,20-dione | - |
Mesocricetus auratus | |
0.167 | - |
5beta-androstan-3,17-dione | - |
Mesocricetus auratus | |
0.233 | - |
5beta-Pregnan-3alpha-ol-20-one | - |
Mesocricetus auratus | |
0.25 | - |
glycolithocholic acid | - |
Mesocricetus auratus | |
0.267 | - |
5alpha-Pregnan-3alpha,21-diol-20-one | - |
Mesocricetus auratus | |
0.367 | - |
5beta-androstan-17beta-ol-3-one | - |
Mesocricetus auratus | |
0.367 | - |
5beta-Pregnan-3alpha,21-diol-20-one | - |
Mesocricetus auratus | |
0.417 | - |
testosterone | - |
Mesocricetus auratus | |
0.45 | - |
5alpha-androstan-3alpha,17beta-diol | - |
Mesocricetus auratus | |
0.85 | - |
5beta-Androstan-3alpha,17beta-diol | - |
Mesocricetus auratus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10.4 | - |
oxidation of 5beta-androstan-3alpha,17beta-diol | Mesocricetus auratus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | preferred | Mesocricetus auratus | |
NADH | preferred | Mesocricetus auratus | |
NADP+ | 15% of NAD+-activity | Mesocricetus auratus | |
NADPH | - |
Mesocricetus auratus |