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Literature summary for 1.1.1.239 extracted from

  • Ashley, R.A.; Yu, Z.; Fung, K.M.; Frimberger, D.; Kropp, B.P.; Penning, T.M.; Lin, H.K.
    Developmental evaluation of aldo-keto reductase 1C3 expression in the cryptorchid testis (2010), Urology, 76, 67-72.
    View publication on PubMed

Application

Application Comment Organism
medicine in patients with cryptorchid testis, AKR1C3 expression occurs in a Tanner stage dependent-fashion. Pre- and peri-pubertal changes appear to promote expression of the enzyme in Leydig cells. In contrast to the normal adult testis, the pediatric cryptorchid testis reveals AKR1C3 expression in Sertoli cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
Leydig cell pre- and peri-pubertal changes promote expression of the enzyme in Leydig cells Homo sapiens
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additional information in patients with cryptorchid testis, no AKR1C3 expression is seen in germ cells at any stage Homo sapiens
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Sertoli cell in contrast to the normal adult testis, the pediatric cryptorchid testis shows AKR1C3 expression in 18%-26% of Sertoli cells in patients at Tanner stages 2 and beyond Homo sapiens
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testis cryptorchid testis. AKR1C3 expression is identified at all ages in fibromyocytes surrounding the testicular tubules Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens AKR1C3 expression occurs in a Tanner stage dependent-fashion additional information