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Literature summary for 1.1.1.247 extracted from

  • Lenz, R.; Zenk, M.H.
    Stereoselective reduction of codeinone, the penultimate enzymic step during morphine biosynthesis in Papaver somniferum (1995), Tetrahedron Lett., 36, 2449-2452.
No PubMed abstract available

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
gel filtration Papaver somniferum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Codeinone + NADPH Papaver somniferum important regulating function in morphine biosynthesis Codeine + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Papaver somniferum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Papaver somniferum
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plant capsule
-
Papaver somniferum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Codeinone + NADPH no reaction with NADH and NAD+ Papaver somniferum Codeine + NADP+
-
?
Codeinone + NADPH important regulating function in morphine biosynthesis Papaver somniferum Codeine + NADP+
-
?
Hydrocodone + NADPH 110% of the reaction with codeinone Papaver somniferum ?
-
?
Hydromorphone + NADPH 90% of the reaction with codeinone Papaver somniferum ?
-
?
Naloxone + NADPH 80% of the reaction with codeinone Papaver somniferum ?
-
?
Naltrexone + NADPH 30% of the reaction with codeinone Papaver somniferum ?
-
?

Subunits

Subunits Comment Organism
monomer 34000-35000, SDS-PAGE Papaver somniferum