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Literature summary for 1.1.1.252 extracted from

  • Thompson, J.E.; Basarab, G.S.; Andersson, A.; Lindqvist, Y.; Jordan, D.B.
    Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism (1997), Biochemistry, 36, 1852-1860.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Tricyclazole
-
Pyricularia grisea

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
Phenanthrenequinone
-
Pyricularia grisea
0.005
-
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one
-
Pyricularia grisea
0.006
-
Scytalone
-
Pyricularia grisea
0.021
-
NADPH with phenanthrenequinone as cosubstrate Pyricularia grisea
0.025 0.033 NADP+ with 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one as cosubstrate Pyricularia grisea
3
-
NAD+ with 2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one as cosubstrate Pyricularia grisea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,3,6,8-Tetrahydroxynaphthalene + NADPH Pyricularia grisea the enzyme is involved in the biosynthesis of melanin Scytalone + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Pyricularia grisea
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,3,6,8-Tetrahydroxynaphthalene + NADPH
-
Pyricularia grisea Scytalone + NADP+ r ?
1,3,6,8-Tetrahydroxynaphthalene + NADPH the enzyme is involved in the biosynthesis of melanin Pyricularia grisea Scytalone + NADP+
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+ ordered sequential mechanism with nucleotide binding first and leaving last Pyricularia grisea vermelone + NADP+
-
?
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NAD+
-
Pyricularia grisea ?
-
?
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+
-
Pyricularia grisea 4,5-Dihydroxy-2H-benzopyran-2-one + NADPH
-
?
Phenanthrenequinone + NADPH
-
Pyricularia grisea ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.38
-
Scytalone
-
Pyricularia grisea
13
-
Phenanthrenequinone
-
Pyricularia grisea
14
-
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one
-
Pyricularia grisea

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Pyricularia grisea
NADP+
-
Pyricularia grisea
NADPH
-
Pyricularia grisea