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Literature summary for 1.1.1.267 extracted from

  • Phaosiri, C.; Proteau, P.J.
    Substrate analogs for the investigation of deoxyxylulose 5-phosphate reductoisomerase inhibition: synthesis and evaluation (2004), Bioorg. Med. Chem. Lett., 14, 5309-5312.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(2S,3R)-dihydroxybutyramide 4-phosphate 50% inhibition at 0.09 mM Synechocystis sp.
(3S)-hydroxypentan-2-one 5-phosphate 50% inhibition at 0.03 mM Synechocystis sp.
(4S)-hydroxypentan-2-one 5-phosphate 50% inhibition at 0.15 mM Synechocystis sp.
1,2-dideoxy-D-threo-3-hexulose 6-phosphate 50% inhibition at 0.63 mM Synechocystis sp.
1-deoxy-L-ribulose 5-phosphate 50% inhibition at 0.18 mM Synechocystis sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.69
-
 (3R,4S)-dihydroxy-5-oxohexylphosphonic acid
-
 Synechocystis sp.

Organism

Organism UniProt Comment Textmining
Synechocystis sp.
-
 strain PCC6803
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3R,4S)-dihydroxy-5-oxohexylphosphonic acid + NADPH
-
 Synechocystis sp. ? + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Synechocystis sp.