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Literature summary for 1.1.1.267 extracted from

  • Fox, D.T.; Poulter, C.D.
    Synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphoric acid analogues as alternate substrates for methylerythritol phosphate synthase (2005), J. Org. Chem., 70, 1978-1985.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,1,1-trifluoro-1-deoxy-D-xylulose 5-phosphoric acid i.e. CF3-DXP, very low inhibition Escherichia coli
1,1-difluoro-1-deoxy-D-xylulose 5-phosphoric acid i.e. CF2-DXP, very low inhibition Escherichia coli
1,2-dideoxy-D-hexulose 6-phosphate i.e. Et-DXP, very low inhibition Escherichia coli
fosmidomycin
-
Escherichia coli
FR900098 specific inhibition Escherichia coli
additional information inhibitor design and synthesis, overview Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
NADPH pH 7.6, 37°C, recombinant enzyme Escherichia coli
0.05
-
1-deoxy-D-xylulose 5-phosphate pH 7.6, 37°C, recombinant enzyme Escherichia coli
0.227
-
1-fluoro-1-deoxy-D-xylulose 5-phosphate pH 7.6, 37°C, recombinant enzyme Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ Escherichia coli
-
2-C-methyl-D-erythritol 4-phosphate + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ reaction mechanism Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
Escherichia coli 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
r
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ i.e. DXP Escherichia coli 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
r
1-fluoro-1-deoxy-D-xylulose 5-phosphate + NADPH i.e. CF-DXP Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
MEP synthase
-
Escherichia coli
methylerythritol phosphate synthase
-
Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
29
-
1-deoxy-D-xylulose 5-phosphate pH 7.6, 37°C, recombinant enzyme Escherichia coli
38
-
1-deoxy-D-xylulose 5-phosphate pH 7.6, 37°C, recombinant enzyme Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2
-
1,1,1-trifluoro-1-deoxy-D-xylulose 5-phosphoric acid pH 7.6, 37°C, recombinant enzyme Escherichia coli
3.4
-
1,1-difluoro-1-deoxy-D-xylulose 5-phosphoric acid pH 7.6, 37°C, recombinant enzyme Escherichia coli
6.2
-
1,2-dideoxy-D-hexulose 6-phosphate pH 7.6, 37°C, recombinant enzyme Escherichia coli