Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,1,1-trifluoro-1-deoxy-D-xylulose 5-phosphoric acid | i.e. CF3-DXP, very low inhibition | Escherichia coli | |
1,1-difluoro-1-deoxy-D-xylulose 5-phosphoric acid | i.e. CF2-DXP, very low inhibition | Escherichia coli | |
1,2-dideoxy-D-hexulose 6-phosphate | i.e. Et-DXP, very low inhibition | Escherichia coli | |
fosmidomycin | - |
Escherichia coli | |
FR900098 | specific inhibition | Escherichia coli | |
additional information | inhibitor design and synthesis, overview | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
NADPH | pH 7.6, 37°C, recombinant enzyme | Escherichia coli | |
0.05 | - |
1-deoxy-D-xylulose 5-phosphate | pH 7.6, 37°C, recombinant enzyme | Escherichia coli | |
0.227 | - |
1-fluoro-1-deoxy-D-xylulose 5-phosphate | pH 7.6, 37°C, recombinant enzyme | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | Escherichia coli | - |
2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | reaction mechanism | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | - |
Escherichia coli | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
r | |
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | i.e. DXP | Escherichia coli | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
r | |
1-fluoro-1-deoxy-D-xylulose 5-phosphate + NADPH | i.e. CF-DXP | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MEP synthase | - |
Escherichia coli |
methylerythritol phosphate synthase | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Escherichia coli |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
29 | - |
1-deoxy-D-xylulose 5-phosphate | pH 7.6, 37°C, recombinant enzyme | Escherichia coli | |
38 | - |
1-deoxy-D-xylulose 5-phosphate | pH 7.6, 37°C, recombinant enzyme | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
1,1,1-trifluoro-1-deoxy-D-xylulose 5-phosphoric acid | pH 7.6, 37°C, recombinant enzyme | Escherichia coli | |
3.4 | - |
1,1-difluoro-1-deoxy-D-xylulose 5-phosphoric acid | pH 7.6, 37°C, recombinant enzyme | Escherichia coli | |
6.2 | - |
1,2-dideoxy-D-hexulose 6-phosphate | pH 7.6, 37°C, recombinant enzyme | Escherichia coli |