Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Yersinia pestis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fosmidomycin | - |
Yersinia pestis | |
FR900098 | - |
Yersinia pestis | |
[3-[acetyl(naphthalen-2-ylmethoxy)amino]propyl]phosphonic acid | compound binds to both the NADPH and DXP sites, while whole-cell inhibitory activity is relatively poor | Yersinia pestis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0127 | - |
NADPH | pH 7.8, 37°C | Yersinia pestis | |
0.222 | - |
1-deoxy-D-xylulose 5-phosphate | pH 7.8, 37°C | Yersinia pestis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
43100 | - |
x * 43100, calculated | Yersinia pestis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Yersinia pestis | Q8ZH62 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | - |
Yersinia pestis | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 43100, calculated | Yersinia pestis |
Synonyms | Comment | Organism |
---|---|---|
IspC | - |
Yersinia pestis |
MEP synthase | - |
Yersinia pestis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | - |
NADPH | pH 7.8, 37°C | Yersinia pestis | |
1.7 | - |
1-deoxy-D-xylulose 5-phosphate | pH 7.8, 37°C | Yersinia pestis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00017 | - |
FR900098 | pH 7.8, 37°C | Yersinia pestis | |
0.00097 | - |
fosmidomycin | pH 7.8, 37°C | Yersinia pestis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00023 | - |
pH 7.8, 37°C | Yersinia pestis | FR900098 | |
0.00071 | - |
pH 7.8, 37°C | Yersinia pestis | fosmidomycin |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
7.3 | - |
1-deoxy-D-xylulose 5-phosphate | pH 7.8, 37°C | Yersinia pestis |