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Literature summary for 1.1.1.27 extracted from

  • Winter, V.J.; Cameron, A.; Tranter, R.; Sessions, R.B.; Brady, R.L.
    Crystal structure of Plasmodium berghei lactate dehydrogenase indicates the unique structural differences of these enzymes are shared across the Plasmodium genus (2003), Mol. Biochem. Parasitol., 131, 1-10.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Plasmodium berghei

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop method of vapour diffusion, ternary complex with NADH and oxamate Plasmodium berghei

Inhibitors

Inhibitors Comment Organism Structure
pyruvate substrate inhibition Plasmodium berghei
pyruvate substrate inhibition Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016
-
 NADH pH 7.5 Plasmodium falciparum
0.021
-
 NADH pH 7.5 Plasmodium berghei
0.049
-
 pyruvate pH 7.5 Plasmodium falciparum
0.057
-
 pyruvate pH 7.5 Plasmodium berghei

Organism

Organism UniProt Comment Textmining
Plasmodium berghei
-
-
-
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Plasmodium berghei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + NADH + H+
-
 Plasmodium falciparum (S)-lactate + NAD+
-
 ?
pyruvate + NADH + H+
-
 Plasmodium berghei (S)-lactate + NAD+
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
94
-
 pyruvate pH 7.5 Plasmodium falciparum
106
-
 pyruvate pH 7.5 Plasmodium berghei

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Plasmodium falciparum
NADH
-
 Plasmodium berghei

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
57
-
 pyruvate pH 7.5 Plasmodium falciparum
66
-
 pyruvate pH 7.5 Plasmodium berghei