Cloned (Comment) | Organism |
---|---|
3-ketosteroid reductase activity of the human 3(alpha-beta)-hydroxysteroid epimerase, stable expression | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
additional information | 3-keto reductase activity in both microsomal fractions and intact cells | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Homo sapiens | - |
3-ketosteroid reductase activity of the human 3(alpha-beta)-hydroxysteroid epimerase | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ | stereoselectivity : #1,4,5# catalyzes reduction of the 3-keto group to a 3beta-hydroxyl group <5,6,7> | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-androstane-3,17-dione + NADPH | 3-ketosteroid reductase activity of the human 3(alpha-beta)-hydroxysteroid epimerase, stereoselective reduction | Homo sapiens | epi-androsterone + NADP+ | epi-ADT | ? | |
5alpha-androstane-3,17-dione + NADPH | 5alpha-dione | Homo sapiens | epi-androsterone + NADP+ | epi-ADT | ? | |
additional information | 3-ketosteroid reductase activity of the human 3(alpha-beta)-hydroxysteroid epimerase catalyzes reduction of 3-ketosteroids to form 3beta-hydroxysteroids | Homo sapiens | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |