Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | no activity | Rattus norvegicus | 5829 | - |
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-pregnan-3,20-dione + NADPH | Rattus norvegicus | biosynthetic pathway, overview | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
5alpha-pregnan-3,20-dione + NADPH | Rattus norvegicus Turku | biosynthetic pathway, overview | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Long-Evans, Turku strain | - |
Rattus norvegicus Turku | - |
male Long-Evans, Turku strain | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
parotid gland | only male rats, no activity in tissues of pregnant and non-pregnant female rats | Rattus norvegicus | - |
salivary gland | only male rats, no activity in tissues of pregnant and non-pregnant female rats | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-pregnan-3,20-dione + NAD(P)H | - |
Rattus norvegicus | 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | i.e. 5alpha-pregnan-3beta-ol-20-one | r | |
5alpha-pregnan-3,20-dione + NAD(P)H | - |
Rattus norvegicus Turku | 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | i.e. 5alpha-pregnan-3beta-ol-20-one | r | |
5alpha-pregnan-3,20-dione + NADPH | biosynthetic pathway, overview | Rattus norvegicus | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
5alpha-pregnan-3,20-dione + NADPH | biosynthetic pathway, overview | Rattus norvegicus Turku | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | cannot substitute for NADPH | Rattus norvegicus | |
NADP+ | - |
Rattus norvegicus | |
NADPH | - |
Rattus norvegicus |