Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.284 extracted from

  • Jelski, W.; Zalewski, B.; Szmitkowski, M.
    The activity of class I, II, III, and IV alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer (2008), Digest. Dis. Sci., 53, 2550-2555.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formaldehyde + glutathione + NAD+ Homo sapiens the enzyme activity in increased in livers from cancer patients independent of alcohol drinking or nondrinking, with no significant differences between primary and metastatic tumors S-formylglutathione + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver from healthy individuals, cancer patients, including drinkers and nondrinkers Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
enzyme activities in livers from healthy individuals, cancer patients, including drinkers and nondrinkers, overview Homo sapiens
0.00089
-
activity in livers from healthy persons, drinkers and nondrinkers Homo sapiens
0.0012
-
activity in livers from cancer patients, drinkers and nondrinkers Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formaldehyde + glutathione + NAD+ the enzyme activity in increased in livers from cancer patients independent of alcohol drinking or nondrinking, with no significant differences between primary and metastatic tumors Homo sapiens S-formylglutathione + NADH + H+
-
?
formaldehyde + glutathione + NAD+ the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione Homo sapiens S-formylglutathione + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
ADH III
-
Homo sapiens
class III ADH
-
Homo sapiens
class III alcohol dehydrogenase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens