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Literature summary for 1.1.1.3 extracted from

  • Grego, S.; Tricoli, D.; Di Marco, G.
    Comparison of homoserine dehydrogenase from different plant sources (1980), Phytochemistry, 19, 1619-1623.
No PubMed abstract available
Search for more literature for 1.1.1.3

Inhibitors

Inhibitors Comment Organism Structure
L-threonine degree of inhibition depends on age of plant; sensitive and insensitive isozymes Pisum sativum
L-threonine degree of inhibition depends on age of plant; sensitive and insensitive isozymes Ricinus communis
L-threonine degree of inhibition depends on age of plant; sensitive and insensitive isozymes Triticum aestivum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.031
-
 NADPH threonine sensitive isozyme Triticum aestivum
0.032 0.036 NADPH threonine resistant isozyme Triticum aestivum
0.043
-
 NADPH threonine sensitive isozyme Triticum aestivum
0.13 0.15 L-aspartate 4-semialdehyde threonine resistant isozyme Triticum aestivum
0.24 0.25 L-aspartate 4-semialdehyde threonine sensitive isozyme Triticum aestivum

Metals/Ions

Metals/Ions Comment Organism Structure
Cs+ activation of threonine sensitive enzyme Triticum aestivum
Cs+ activation of threonine sensitive enzyme Pisum sativum
Cs+ activation of threonine sensitive enzyme Ricinus communis
K+ activation of threonine sensitive isozyme Triticum aestivum
K+ activation of threonine sensitive isozyme Pisum sativum
K+ activation of threonine sensitive isozyme Ricinus communis
Li+ activation of threonine sensitive isozyme Triticum aestivum
Li+ activation of threonine sensitive isozyme Pisum sativum
Li+ activation of threonine sensitive isozyme Ricinus communis
Na+ activation of threonine sensitive form Triticum aestivum
Na+ activation of threonine sensitive form Pisum sativum
Na+ activation of threonine sensitive form Ricinus communis
NH4+ activation of threonine sensitive isozyme Triticum aestivum
NH4+ activation of threonine sensitive isozyme Pisum sativum
NH4+ activation of threonine sensitive isozyme Ricinus communis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
 gel filtration, threonine insensitive isozyme Triticum aestivum
75000
-
 gel filtration, threonine insensitive isozyme Pisum sativum
80000
-
 disc gel electrophoresis, threonine insensitive isozyme Ricinus communis
280000
-
 disc gel electrophoresis, threonine sensitive isozyme Ricinus communis
290000
-
 gel filtration, threonine sensitive isozyme Triticum aestivum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate 4-semialdehyde + NAD(P)H Triticum aestivum
-
 L-homoserine + NAD(P)+
-
 r
L-aspartate 4-semialdehyde + NAD(P)H Pisum sativum
-
 L-homoserine + NAD(P)+
-
 r
L-aspartate 4-semialdehyde + NAD(P)H Ricinus communis
-
 L-homoserine + NAD(P)+
-
 r

Organism

Organism UniProt Comment Textmining
Pisum sativum
-
 pea
-
Ricinus communis
-
 castor bean
-
Triticum aestivum
-
 wheat
-

Purification (Commentary)

Purification (Comment) Organism
-
 Triticum aestivum
-
 Pisum sativum
-
 Ricinus communis

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
 Triticum aestivum
-
seedling
-
 Pisum sativum
-
seedling
-
 Ricinus communis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.17
-
-
 Triticum aestivum
2.8
-
-
 Pisum sativum
6.8
-
-
 Ricinus communis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate 4-semialdehyde + NAD(P)H
-
 Triticum aestivum L-homoserine + NAD(P)+
-
 r
L-aspartate 4-semialdehyde + NAD(P)H
-
 Pisum sativum L-homoserine + NAD(P)+
-
 r
L-aspartate 4-semialdehyde + NAD(P)H
-
 Ricinus communis L-homoserine + NAD(P)+
-
 r
L-homoserine + NAD(P)+
-
 Triticum aestivum L-aspartate 4-semialdehyde + NAD(P)H
-
 r
L-homoserine + NAD(P)+
-
 Pisum sativum L-aspartate 4-semialdehyde + NAD(P)H
-
 r
L-homoserine + NAD(P)+
-
 Ricinus communis L-aspartate 4-semialdehyde + NAD(P)H
-
 r

Cofactor

Cofactor Comment Organism Structure
NADH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Triticum aestivum
NADH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Pisum sativum
NADH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Ricinus communis
NADPH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Triticum aestivum
NADPH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Pisum sativum
NADPH threonine sensitive isozyme can use NADPH or NADH, threonine insensitive isozyme can use NADPH only Ricinus communis