Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lovastatin | competitive inhibitor for HMG-CoA binding site and noncompetitive inhibitor for NADPH binding site | Trypanosoma cruzi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.028 | - |
3-hydroxy-3-methylglutaryl-CoA | - |
Trypanosoma cruzi | |
0.037 | - |
NADPH | - |
Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Trypanosoma cruzi | 5829 | - |
glycosome | - |
Trypanosoma cruzi | 20015 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA + NADPH | Trypanosoma cruzi | - |
(R)-mevalonate + CoA + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
Schizotrypanum | - |
Purification (Comment) | Organism |
---|---|
- |
Trypanosoma cruzi |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0164 | - |
- |
Trypanosoma cruzi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Trypanosoma cruzi | (R)-mevalonate + CoA + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Trypanosoma cruzi |