Literature summary for 1.1.1.34 extracted from

Leopoldini, M.; Malaj, N.; Toscano, M.; Sindona, G.; Russo, N.
On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme (2010), J. Agric. Food Chem., 58, 10768-10773.

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Inhibitors

Inhibitors	Comment	Organism	Structure
brutieridin	i.e. hesperetin 7-(2''-alpha-rhamnosyl-6''-(3''''-hydroxy-3''''-methylglutaryl)-beta-D-glucoside), a flavonoid conjugate from bergamot fruit extract, structural analogue of statins, computational study, overview	Homo sapiens
melitidin	i.e. naringenin 7-(2''-alpha-rhamnosyl-6''-(3''''-hydroxy-3''''-methylglutaryl)-beta-D-glucoside), a flavonoid conjugate from bergamot fruit extract, structural analogue of statins, computational study, overview	Homo sapiens
additional information	statins are potent enzyme inhibitors that bind to the active site where also the natural substrate binds, used widely in the treatment of hypercholesterolemia	Homo sapiens
simvastatin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P04035	-	-

Synonyms

Synonyms	Comment	Organism
3-hydroxy-3-methylglutaryl-CoA reductase	-	Homo sapiens
HMGR	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens
NADPH	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	HMGR catalyzes the four-electron reduction of HMGCoA to mevalonate, the committed step in the biosynthesis of sterols. Mevalonate is a precursor of isoprenoids, a class of compounds involved in several cellular functions such as cholesterol synthesis and growth control	Homo sapiens
additional information	modelling of the active site using crystal stucture of the enzyme with bound inhibitor simvastatin, PDB ID 1HW9, overview	Homo sapiens
physiological function	within cells, the concentration of mevalonate and therefore that of its metabolic products is tightly controlled through the activity of HMGR, an enzyme that catalyzes the four-electron reduction of 3-hydroxy-3-methylglutaryl-CoA to mevalonate	Homo sapiens

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Release 2023.1 (January 2023)