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Literature summary for 1.1.1.35 extracted from

  • He, X.Y.; Schulz, H.; Yang, S.Y.
    a human brain L-3-hydroxyacyl-coenzyme a dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease (1998), J. Biol. Chem., 273, 10741-10746.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
NADH enzyme from brain Homo sapiens
0.089
-
acetoacetyl-CoA enzyme from brain Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
4 * 27000, enzyme from brain, SDS-PAGE Homo sapiens
108000
-
enzyme from brain, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxybutyryl-CoA + NAD+ Homo sapiens
-
acetoacetyl-CoA + NADH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens Q99714
-
-

Purification (Commentary)

Purification (Comment) Organism
overexpressed in Escherichia coli, hydroxylapatite Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
17.35
-
enzyme from brain Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-hydroxybutyryl-CoA + NAD+
-
Homo sapiens acetoacetyl-CoA + NADH
-
r
3-ketohexadecanoyl-CoA + NADH
-
Homo sapiens (S)-3-hydroxhexadecanoyl-CoA + NAD+
-
r
3-ketooctanoyl-CoA + NADH
-
Homo sapiens (S)-3-hydroxyoctanoyl-CoA + NAD+
-
r

Subunits

Subunits Comment Organism
tetramer 4 * 27000, enzyme from brain, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
24
-
3-ketohexdecanoyl-CoA enzyme from brain, pH 7.0 Homo sapiens
28
-
3-ketooctanoyl-CoA enzyme from brain, pH 7.0 Homo sapiens
37
-
acetoacetyl-CoA enzyme from brain, pH 7.0 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens